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-  2019 

Epithelial-Mesenchymal Transition Directs Stem Cell Polarity via Regulation of Mitofusin

DOI: https://doi.org/10.1016/j.cmet.2018.11.004

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Abstract:

? EMT induces mitochondrial fusion through upregulation of MFN1 ? MFN1 is required for PKCζ-mediated NUMB phosphorylation for asymmetric cell division ? MFN1-PKCζ tethers fused mitochondria for segregation into stem cell progeny ? Mitochondrial fusion enhances GSH synthesis to promote stem cell self-renewa

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