Dynamic Changes in the Niche with N-Cadherin Revisited: The HSC “Niche Herein”

Recently in Cell Reports, Zhao et al. report that chemo-resistant (reserve) hematopoietic stem cells (HSCs) are maintained in the endosteal niche under the influence of N-cadherin+ bone-lining cells ( Zhao et al., 2019 Zhao M. Tao F. Venkatraman A. Li Z. Smith S.E. Unruh J. Chen S. Ward C. Qian P. Perry J.M. et al. N-Cadherin-Expressing Bone and Marrow Stromal Progenitor Cells Maintain Reserve Hematopoietic Stem Cells. Cell Rep. 2019; 26 : 652-669.e6 Abstract Full Text Full Text PDF PubMed Scopus (1) Google Scholar ). These findings further indicate that niches for bone marrow HSCs may differ dynamically during physiological and stress hematopoiesis