Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity

？ SIRT1 expression is frequently decreased in aggressive breast cancers ？ Reducing SIRT1 levels in breast cancer cells impairs lysosomal acidification ？ Loss of SIRT1 gives rise to a secretome that promotes cell invasion and survival ？ SIRT1 mediates these effects by regulating V-ATPase expressio