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-  2019 

FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration

DOI: https://doi.org/10.1016/j.stem.2018.12.002

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Abstract:

? Recoding of two nucleotides in FOXO3 gene is sufficient to activate FOXO3 activity ? Genetic activation of FOXO3 reinforces the homeostasis of human vascular cells ? FOXO3-enhanced vascular cells promote revascularization after ischemic surgery ? FOXO3-activated human stem cells are resistant to oncogenic transformatio

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