Chelation Therapy and Chelating Ligands for Iron Overload

Iron overload is a condition of excess iron stores in different parts of body which can be largely prevented by the use of chelating agents. The human body doesn’t have any a physiological mechanism to eliminate iron overload. Currently applied methods for treatment of iron overload consisting of chelation therapy. Iron chelation therapy involves the use of ligating drugs that avidly bind iron for the treatment of potentially iron overload disease. In this review, we tried to give information about the reasons for the occurrence of iron overload in the human body, the latest developments in chelators and chelators that are in the trial phase at the clinic