The effect of beta-hydroxybutyrate level on other metabolic test parameters

Metabolic profile test was performed to determine the metabolic status of dairy cattle and to use in the early diagnosis of metabolic diseases. The aim of this study was to determine the changes in metabolic profile test parameters of dairy cattle with negative energy balances and the relationships between these parameters. The metabolic profile results of 189 cattle within the first 2 wk of lactation period were evaluated retrospectively. Animals with a Beta-hydroxybutyrate (BHBA) threshold level above 1 mmol/L were assigned to Group-1 and the animals with blood BHBA levels less than 1 mmol/L to Group-2. BHBA level was assessed by blood ketone meter. Glucose, blood urea nitrogen (BUN), magnesium (Mg), aspartate aminotransferase (AST), phosphorus (P), cholesterol, total protein, albumin, calcium and gamma glutamyl transferase (GGT) analyzes were performed by the auto-analyzer. Group-1 levels of glucose (p<0.001) and albumin (p<0.01) were found to be significantly lower, GGT (p<0.001), AST (p<0.05), and calcium (p<0.01) were significantly higher than Group-2. BHBA level was found to be negatively correlated with glucose (p<0.01) and with a positive correlation with AST (p<0.01) and GGT (p<0.01). In conclusion, the enzymes showing liver damage started to increase when BHBA value was above 1 mmol/L. In addition to the treatment of the negative energy balance in the cattle with subclinical ketosis, it was concluded that supportive therapies for the liver should be performed and check the risk of the fatty liver in herd