The compar？son of treatment effectiveness of carnosol and dexamethasone in rats with lung contus？on

Aim Excessive stretching and tearing in the alveoli after trauma, separation of the alveoli from the bronchioles,intraalveolar hemorrhage, interstitial edema and alveolocapillary damage resulting from the trauma are expressed as lung contusion. In recent years, the number of studies on the effects of antioxidants on the experimental lung contusion model has been increasing steadily. The aim of this study is to investigate the efficacy of carnosol and dexamethasone in traumatic lung contusion. Material and Method In this study 50 Wistar Albino female rats in a weight range of 180-220 g and in a age rage of 6-8 months we’re used. The rats we’re divided into five equal main groups (n = 10). Groups we’re designed as; sham group, control group with only lung contusion, carnosol group which are given carnosol 30 minutes after lung contusion, dexamethasone group which are given dexamethasone 30 minutes after lung contusion and carnosol dexamethasone group which we’re administered carnosol and dexamethasone 30 minutes after lung contusion. After 48 hours, the rats we’re sacrificed under anesthesia. Right lung tissue was taken for both histopathological examination and biochemical examination. Blood samples taken we’re evaluated for biochemical examination. Results Total oxidant, total antioxidant and oxidative stress levels were measured and histopathologic changes we’re examined in the serum and tissue samples. In our study, pathologic examination of carnosol and dexamethasone groups showed statistically significant improvement in terms of interstitial edema (p=0,048), interstitial hemorrhage (p=0,014) and alveolar congestion (p<0,01) compared to the control group. The TOS value was lower in the treatment groups and the highest TOS value was in the trauma model but there was no statistically significant difference between all groups. Conclusion As a result; Carnosolone and dexamethasone used in lung contusion-induced rats; can have an effect of avoiding adverse effects of contusion, especially when histopathological evaluations are taken into consideration