Background: Salivary gland tumours (SGTs) are rare, but recent reports suggest an increasing incidence. Although there are previous Nigerian studies on the patterns of SGTs, patterns and trends of disease may change over time. The aim of this study was to describe the pattern of presentation of SGTs, and to determine the trends in occurrence of SGTs at Federal Teaching Hospital (FTH), Gombe over a period of 15 years. Method: This descriptive study included cases of histologically diagnosed SGTs from January 2008 to December 2022. Relevant information (age, gender, site, year of diagnosis, and histopathologic diagnosis) was extracted from the cancer registers and histopathologic records. The lesions were then categorized into benign and malignant SGTs and grouped into three groups spanning 5 years each based on the year of diagnosis. Data analysis was done using IBM SPSS version 23, and p ≤ 0.05 was considered statistically significant. Results: There were 93 (61.2%) benign and 59 (38.8%) malignant SGTs. Benign SGTs had a mean age of 36.4 ± 13.6 years, and were more common in females (57.0%), and in the parotid (41.9%). Pleomorphic adenoma (94.6%) was the most common benign SGT. Malignant SGTs had a mean age of 44.5 ± 18.4 years, with male predilection (54.2%) and occurrence mostly in the palate (27.6%) and parotid (22.4%). Mucoepidermoid carcinoma (39.0%) and adenoid cystic carcinoma (32.2%) were the most frequent malignant SGTs. The mean age of occurrence of malignant SGTs was significantly higher than that of benign SGTs (p = 0.005). The trend analysis showed that there has been a steady rise in the proportion of males presenting with malignant SGTs. Similarly, there has been a steady increase in the frequency of benign SGTs in the parotid. The palate was the predominant site for the malignant SGTs between 2008 and 2012, but in the last five years (2018 to 2022), the parotid has become the predominant site. Over the duration of the study, the ratio of benign to malignant SGTs has remained relatively constant. Conclusion: While the overall pattern of presentation of SGTs in Gombe is similar to reports in the literature, this study has identified some changes in trends over the years.
References
[1]
Nanci, A. and Causa, H. (2018) Ten Cate’s Oral Histology Development, Structure, and Function. 9th Edition, Elsevier, St. Louis.
[2]
El-Naggar, A.K., Chan, J.K.C., Rubin Grandis, J., Takata, T. and Slootweg, P.J. (2017) WHO Classification of Head and Neck Tumours. 4th Edition, rld Health Organization, Lyon.
[3]
Alsanie, I., Rajab, S., Cottom, H., Adegun, O., Agarwal, R., Jay, A., et al. (2022) Distribution and Frequency of Salivary Gland Tumours: An International Multicenter Study. Head and Neck Pathology, 16, 1043-1054. https://doi.org/10.1007/s12105-022-01459-0
[4]
Omitola, O.G., Soyele, O.O., Butali, A., Akinshipo, A.O., Okoh, D., Sigbeku, O., et al. (2019) Descriptive Epidemiology of Salivary Gland Neoplasms in Nigeria: An AOPRC Multicenter Tertiary Hospital Study. Oral Diseases, 25, 142-149. https://doi.org/10.1111/odi.12956
[5]
Galdirs, T.M., Kappler, M., Reich, W. and Eckert, A.W. (2019) Current Aspects of Salivary Gland Tumors—A Systematic Review of the Literature. GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW, 8, Doc12.
[6]
Chiruvella, V., Black, W. and Guddati, A.K. (2022) Increasing Trends in Mortality Rate among Salivary Gland Tumors in Non-Geriatric African Americans. World Journal of Oncology, 13, 96-101. https://doi.org/10.14740/wjon1420
[7]
Seok, J., Park, E.H., Jung, K.W. and Chang, J.W. (2022) Recent Trends in the Incidence of Salivary Gland Malignancies. Korean Society for Head and Neck Oncology, 38, 1–5. https://doi.org/10.21593/kjhno/2022.38.2.1
[8]
Osayande, O., Obahiagbon, I. and Omoregie, O. (2017) A Clinicopathologic Study of Salivary Gland Neoplasms in a South-South Nigerian Population. Nigerian Journal of Dental Research, 2, 61-71.
[9]
Lawal, A.O., Adisa, A.O., Kolude, B., Adeyemi, B.F. and Olajide, M.A. (2013) A Review of 413 Salivary Gland Tumours in the Head and Neck Region. Journal of Clinical and Experimental Dentistry, 5, 218-222. https://doi.org/10.4317/jced.51143
[10]
Otoh, E.C., Mandong, B.M., Danfillo, I.S. and Jalo, P.H. (2006) Salivary Gland Tumours: A 16-Year Review at Jos University Teaching. Nigerian Journal of Clinical & Biomedical Research, 1, 51-57.
[11]
Braimah, R., Taiwo, A., Ibikunle, A. and Sahabi, S. (2018) Clinico-Pathologic Review of Salivary Glands Neoplasms in a Nigerian University Teaching Hospital: A Five Year Retrospective Survey. International Biological and Biomedical Journal, 4, 104-111.
[12]
Nzegwu, M.A., Ngozi, N.R., Ugochukwu, A.I., Amu, C., Okolugbe, N., Okoye, L.O., et al. (2011) A Review of Salivary Gland Neoplasms in Eastern Nigeria for a Five-Year Period from. Advanced Biomedical Research, 2, 28-32.
[13]
Aliyu, D., Robert Iseh, K., Mallami Sahabi, S., Baba Amutta, S., Abdullahi, M. and Inoh, M.I. (2016) Pattern of Salivary Gland Tumour in Sokoto, North-Western Nigeria. International Journal of Clinical Medicine, 7, 347-352. https://doi.org/10.4236/ijcm.2016.75037
[14]
Alabi, B.S., Rahman, G.A., Ibrahim, O.O.O., Afolabi, O.A. and Omokanye, H.K. (2013) Descriptive Analysis of Salivary Gland Tumours in Ilorin, Nigeria. Nigerian Quarterly Journal of Hospital Medicine, 23, 213-216.
[15]
Lawal, A.O., Adisa, A.O., Kolude, B. and Adeyemi, B.F. (2015) Malignant Salivary Gland Tumours of the Head and Neck Region: A Single Institutions Review. The Pan African Medical Journal, 20, Article 121. https://doi.org/10.11604/pamj.2015.20.121.3458
[16]
Baingana, F. and Bos, E.R. (2006) Changing Patterns of Disease and Mortality in Sub-Saharan Africa: An Overview. In: Jamison, D., Feachem, R., Makgoba, M., Bos, E., Baingana, F., Hofman, K., et al., Eds., Disease and Mortality in Sub-Saharan Africa, The International Bank for Reconstruction and Development and The World Bank, Washington DC, 1-9.
[17]
Schettler, T. (2002) A Challenge to Health-Care Providers—Changing Patterns of Disease: Human Health and the Environment. San Francisco Marin Medicine, 75.
[18]
Jude, U. and Olu-Eddo, A. (2014) Salivary Gland Tumors, a Twenty-Year Retrospective Study. African Journal of Medical and Health Sciences, 13, 24.
[19]
Olatunde Oluleke, O., Godwin, A.I., Benjamin, F., Modupe, O. and Yates, S. (2021) Salivary Gland Tumours in the Intraoral Region: A Retrospective Study of Cases Treated in a Teaching Hospital in North-West Nigeria. African Journal of Medical and Health Sciences, 20, 47-52.
[20]
Akpeh, J., Okechi, U.C. and Ezeanolue, B. (2022) Primary Minor Salivary Gland Tumors: A Retrospective Review of Cases Seen in a Tertiary Institution in South East Nigeria. Nigerian Journal of Clinical Practice, 25, 368-372.
[21]
Otoh, E.C., Johnson, N.W., Olasoji, H., Danfillo, I.S. and Adeleke, O.A. (2005) Salivary Gland Neoplasms in Maiduguri, North-Eastern Nigeria. Oral Diseases, 11, 386-391. https://doi.org/10.1111/j.1601-0825.2005.01137.x
[22]
Otoh, E.C., Johnson, N.W., Olasoji, H., Danfillo, I.S. and Adeleke, O.A. (2005) Intra-Oral Carcinomas in Maiduguri, North-Eastern Nigeria. Oral Diseases, 11, 379-385. https://doi.org/10.1111/j.1601-0825.2005.01134.x
[23]
Fakuade, B.O., Orikpete, E.V., Obimakinde, O.S., Lawan, A.I. and Omitola, O.G. (2022) Oral Histopathological Diagnosis: A 6-Year Audit at a Tertiary Hospital in Gombe, North-East Nigeria. Nigerian Journal of Medicine, 31, 681-685. https://doi.org/10.4103/NJM.NJM_117_22
[24]
Akinmoladun, V., Akintububo, O., Ojo, E., Ayuba, D. and Adisa, A. (2013) Evaluation of the Histopathology of Orofacial Lesions in a North-East Nigerian Tertiary Centre. Annals of African Medicine, 12, 105-109. https://doi.org/10.4103/1596-3519.112401
[25]
Saghravanian, N., Ghazi, N. and Saba, M. (2013) Clinicopathologic Evaluation of Salivary Gland Neoplasms: A 38-Year Retrospective Study in Iran. Annals of Diagnostic Pathology, 17, 522-525. https://doi.org/10.1016/j.anndiagpath.2013.05.008
[26]
Oti, A.A., Donkor, P., Obiri-Yeboah, S. and Afriyie-Owusu, O. (2013) Salivary Gland Tumours at Komfo Anokye Teaching Hospital, Ghana. Surgical Science, 4, 135-139. https://doi.org/10.4236/ss.2013.42026
[27]
Li, L., Li, Y., Wen, Y., Liu, H. and Zhao, H. (2008) Clinical Analysis of Salivary Gland Tumor Cases in West China in Past 50 Years. Oral Oncology, 44, 187-192. https://doi.org/10.1016/j.oraloncology.2007.01.016
[28]
Fonseca, F.P., De Vasconcelos Carvalho, M., De Almeida, O.P., Rangel, A.L.C.A., Takizawa, M.C.H., Bueno, A.G., et al. (2012) Clinicopathologic Analysis of 493 Cases of Salivary Gland Tumors in a Southern Brazilian Population. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, 114, 230-239. https://doi.org/10.1016/j.oooo.2012.04.008
[29]
Parkins, G.E., Blankson, P.K., Affum, A., Boamah, M.O. and Sackeyfio, J. (2021) Salivary Gland Neoplasms: A 10-Year Review of a Major Referral Center in Ghana. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, 131, 161-165. https://doi.org/10.1016/j.oooo.2020.08.010
[30]
Cunha, J.L.S., Coimbra, A.C.P., Silva, J.V.R., Do Nascimento, I.S., de Andrade, M.E., de Oliveira, C.R., et al. (2020) Epidemiologic Analysis of Salivary Gland Tumors over a 10-Years Period Diagnosed in a Northeast Brazilian Population. Medicina Oral, Patologia Oral y Cirugia Bucal, 25, e516-e522. https://doi.org/10.4317/medoral.23532
[31]
de Oliveira, F.A., Duarte, E.C.B., Taveira, C.T., Máximo, A.A., de Aquino, é.C., de Cássia Alencar, R., et al. (2009) Salivary Gland Tumor: A Review of 599 Cases in a Brazilian Population. Head and Neck Pathology, 3, 271-275. https://doi.org/10.1007/s12105-009-0139-9
[32]
Subhashraj, K. (2008) Salivary Gland Tumors: A Single Institution Experience in India. British Journal of Oral and Maxillofacial Surgery, 46, 635-638. https://doi.org/10.1016/j.bjoms.2008.03.020
[33]
Karipidis, K., Mate, R., Sanagou, M., Brzozek, C., Urban, D. and Elwood, M. (2021) Mobile Phone Use and Trends in the Incidence of Cancers of the Parotic and Other Salivary Glands. Cancer Epidemiology, 73, Article ID: 101961. https://doi.org/10.1016/j.canep.2021.101961
[34]
Awe, O.O., Obed, R.I., Adekanmi, A.J., Ogbole, G.I. and Agbele, A.T. (2021) Thyroid Dose and Cancer Risk from Head and Neck Computed Tomography at Two Selected Centres in Nigeria. Nigerian Postgraduate Medical Journal, 28, 278-284. https://doi.org/10.4103/npmj.npmj_611_21
[35]
de Siqueira, E.C., de Souza, F.T.A., Gomez, R.S., Gomes, C.C. and de Souza, R.P. (2017) Does Cell Phone Use Increase the Chances of Parotid Gland Tumor Development? A Systematic Review and Meta-Analysis. Journal of Oral Pathology & Medicine, 46, 480-483. https://doi.org/10.1111/jop.12531
