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The Function of Oxytocin in Memory
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Abstract:
Introduction: While oxytocin (OT) is widely recognized for its pivotal role in reproductive behavior and the formation of social bonds, there remains a significant gap in our understanding of its potential influence on learning and memory processes, encompassing both social and non-social aspects. Thus this paper serves as an attempt to investigate the comprehensive role of OT in Physiological, Cognitive, and Behavioral processes. Method: A comprehensive literature review was conducted to assemble evidence related to the influence of OT on learning and memory. Studies encompassing both social and non-social memory were incorporated into the analysis. Additionally, molecular mechanisms through which OT could potentially impact neuronal activity in the hippocampus and amygdala, consequently affecting learning and memory, were also investigated. Results: Our review reveals a spectrum of evidence that both supports and contradicts the theory that OT plays a significant role in social and non-social memory. While certain studies suggest a positive impact of OT on memory, others present findings that argue otherwise. However, multiple potential molecular mechanisms were discovered that may elucidate OT’s effects on learning and memory, particularly its potential to modulate neuronal activity in the hippocampus and amygdala. Conclusion: Despite the mixed evidence, OT might have a significant role in both social and non-social memory. Identified molecular mechanisms propose potential ways in which OT could influence learning and memory. The key role appears to be the modulation of neuronal activity in the hippocampus and amygdala by OT. Furthermore, it is plausible that OT’s function in memory is crucial for the social behaviors previously associated with it. Future research is necessitated to fully unravel the exact mechanisms and implications of OT’s role in learning and memory.
| [1] | rakbar@rambler.ru 密码 akhmedovBethlehem, R.A.I., van Honk, J., Auyeung, B. and Baron-Cohen, S. (2013) Oxytocin, Brain Physiology, and Functional Connectivity: A Review of Intranasal Oxytocin FMRI Studies. Psychoneuroendocrinology, 38, 962-974.
https://doi.org/10.1016/j.psyneuen.2012.10.011 |
| [2] | MacDonald, K. and MacDonald, T.M. (2010) The Peptide That Binds: A Systematic Review of Oxytocin and Its Prosocial Effects in Humans. Harvard Review of Psychiatry, 18, 1-21. https://doi.org/10.3109/10673220903523615 |
| [3] | Di Simplici, M. and Harmer, C.J. (2016) Oxytocin and Emotion Processing. Journal of Psychopharmacology, 30, 1156-1159. https://doi.org/10.1177/0269881116641872 |
| [4] | Carcea, I., Caraballo, N.L., Marlin, B.J., Ooyama, R., Riceberg, J.S., Mendoza Navarro, J.M., Opendak, M., et al. (2021) Oxytocin Neurons Enable Social Transmission of Maternal Behaviour. Nature, 596, 553-557.
https://doi.org/10.1038/s41586-021-03814-7 |
| [5] | Marlin, B.J., Mitre, M., D’amour, J.A., Chao, M.V. and Froemke, R.C. (2015) Oxytocin Enables Maternal Behaviour by Balancing Cortical Inhibition. Nature, 520, 499-504. https://doi.org/10.1038/nature14402 |
| [6] | Lee, A., Clancy, S. and Fleming, A. (2000) Mother Rats Bar-Press for Pups: Effects of Lesions of the Mpoa and Limbic Sites on Maternal Behavior and Operant Responding for Pup-Reinforcement. Behavioural Brain Research, 100, 15-31.
https://doi.org/10.1016/S0166-4328(98)00109-0 |
| [7] | Ågmo, A. (2007) Neural Control of Sexual Behavior. In: Ågmo, A., Ed., Functional and Dysfunctional Sexual Behavior, Academic Press, Cambridge, 231-256.
https://doi.org/10.1016/B978-012370590-7/50007-4 |
| [8] | Young, L.J. and Wang, Z.X. (2004) The Neurobiology of Pair Bonding. Nature Neuroscience, 7, 1048-1054. https://doi.org/10.1038/nn1327 |
| [9] | Berendzen, K.M., Sharma, R., Mandujano, M.A., Wei, Y.C., Rogers, F.D., Simmons, T.C., Seelke, A.M.H., et al. (2023) Oxytocin Receptor Is Not Required for Social Attachment in Prairie Voles. Neuron, 111, 787-796.E4.
https://doi.org/10.1016/j.neuron.2022.12.011 |
| [10] | Takahashi, J., Yamada, D., Ueta, Y., Iwai, T., Koga, E., Tanabe, M., Oka, J.I. and Saitoh, A. (2020) Oxytocin Reverses Aβ-Induced Impairment of Hippocampal Synaptic Plasticity in Mice. Biochemical and Biophysical Research Communications, 528, 174-178. https://doi.org/10.1016/j.bbrc.2020.04.046 |
| [11] | Gimpl, G. and Fahrenholz, F. (2001) The Oxytocin Receptor System: Structure, Function, and Regulation. Physiological Reviews, 81, 629-683.
https://doi.org/10.1152/physrev.2001.81.2.629 |
| [12] | Zagrean, A.M., Georgescu, I.A., Iesanu, M.I., Ionescu, R.B., Haret, R.M., Panaitescu, A.M. and Zagrean, L. (2022) Oxytocin and Vasopressin in the Hippocampus. Vitamins and Hormones, 118, 83-127. https://doi.org/10.1016/bs.vh.2021.11.002 |
| [13] | Wahis, J., Baudon, A., Althammer, F., Kerspern, D., Goyon, S., Hagiwara, D., Hagiwara, D., et al. (2021) Astrocytes Mediate the Effect of Oxytocin in the Central Amygdala on Neuronal Activity and Affective States in Rodents. Nature Neuroscience, 24, 529-541. https://doi.org/10.1038/s41593-021-00800-0 |
| [14] | Zing, H.H. and Laporte, S.A. (2003) The Oxytocin Receptor. Trends in Endocrinology and Metabolism, 14, 222-227. https://doi.org/10.1016/S1043-2760(03)00080-8 |
| [15] | Popik, P. and van Ree, J.M. (1991) Oxytocin But Not Vasopressin Facilities Social Recognition following Injection into the Medial Preoptic Area of the Rat Brain. European Neuropsychopharmacology, 1, 555-560.
https://doi.org/10.1016/0924-977X(91)90010-R |
| [16] | Ferguson, J.N., Young, L.J., Hearn, E.F., Matzuk, M.M., Insel, T.R. and Winslow, J.T. (2000) Social Amnesia in Mice Lacking the Oxytocin Gene. Nature Genetics, 25, 284-288. https://doi.org/10.1038/77040 |
| [17] | Moslemi, M., Khodagholi, F., Asadi, S., Rafiei, S. and Motamedi, F. (2020) Oxytocin Protects against 3-NP Induced Learning and Memory Impairment in Rats: Sex Differences in Behavioral and Molecular Responses to the Context of Prenatal Stress. Behavioural Brain Research, 379, Article ID: 112354.
https://doi.org/10.1016/j.bbr.2019.112354 |
| [18] | Eckstein, M., Scheele, D., Patin, A., Preckel, K., Becker, B., Walter, A., Domschke, K., et al. (2016) Oxytocin Facilitates Pavlovian Fear Learning in Males. Neuropsychopharmacology, 41, 932-939. https://doi.org/10.1038/npp.2015.245 |
| [19] | Hurlemann, R., Hurlemann, R., Patin, A., Onur, O.A., Onur, O.A., Cohen, M.X., Baumgartner, T., et al. (2010) Oxytocin Enhances Amygdala-Dependent, Socially Reinforced Learning and Emotional Empathy in Humans. The Journal of Neuroscience, 30, 4999-5007. https://doi.org/10.1523/JNEUROSCI.5538-09.2010 |
| [20] | Guastella, A.J., Mitchell, P.B. and Dadds, M.R. (2008) Oxytocin Increases Gaze to the Eye Region of Human Faces. Biological Psychiatry, 63, 3-5.
https://doi.org/10.1016/j.biopsych.2007.06.026 |
| [21] | Brambilla, M., Manenti, R., de Girolamo, G., Adenzato, M., Bocchio-Chiavetto, L. and Cotelli, M. (2016) Effects of Intranasal Oxytocin on Long-Term Memory in Healthy Humans: A Systematic Review. Drug Development Research, 77, 479-488.
https://doi.org/10.1002/ddr.21343 |
| [22] | Lin, Y.T., Hsieh, T.Y., Tsai, T.C., Chen, C.C., Huang, C.C. and Hsu, K.S. (2017) Conditional Deletion of Hippocampal CA2/CA3a Oxytocin Receptors Impairs the Persistence of Long-Term Social Recognition Memory in Mice. The Journal of Neuroscience, 38, 1218-1231. https://doi.org/10.1523/JNEUROSCI.1896-17.2017 |
| [23] | Fang, L.Y., Quan, R.D. and Kaba, H. (2008) Oxytocin Facilitates the Induction of Long-Term Potentiation in the Accessory Olfactory Bulb. Neuroscience Letters, 438, 133-137. https://doi.org/10.1016/j.neulet.2007.12.070 |
| [24] | Medina, C., Krawczyk, M.C., Millan, J., Blake, M.G. and Boccia, M.M. (2022) Oxytocin-Cholinergic Central Interaction: Implications for Non-Social Memory Formation. Neuroscience, 497, 73-85. https://doi.org/10.1016/j.neuroscience.2022.06.028 |
| [25] | Liao, Z.J., Huang, L.Q. and Luo, S.Y. (2020) intranasal Oxytocin Decreases Self-Oriented Learning. Psychopharmacology, 238, 461-474.
https://doi.org/10.1007/s00213-020-05694-7 |
| [26] | Wagner, U. and Echterhoff, G. (2018) When Does Oxytocin Affect Human Memory Encoding? The Role of Social Context and Individual Attachment Style. Frontiers in Human Neuroscience, 12, Article 370072.
https://doi.org/10.3389/fnhum.2018.00349 |
| [27] | del Rio, T., van den Burg, E.H., Stoop, R., Hegoburu, C., Hegoburu, C. and Hegoburu, C. (2019) Acute and Long-Lasting Effects of Oxytocin in Cortico-Limbic Circuits: Consequences for Fear Recall and Extinction. Psychopharmacology, 236, 339-354. https://doi.org/10.1007/s00213-018-5030-5 |
| [28] | Bazaz, A., Ghanbari, A., Ali Vafaei, A., Khaleghian, A., Rashidy-Pour, A. and Rashidy Pour, A. (2022) Oxytocin in Dorsal Hippocampus Facilitates Auditory Fear Memory Extinction in Rats. Neuropharmacology, 202, Article ID: 108844.
https://doi.org/10.1016/j.neuropharm.2021.108844 |
| [29] | Eckstein, M., Becker, B., Scheele, D., Scholz, C., Preckel, K., Schlaepfer, T.E., Grinevich, V., et al. (2015) Oxytocin Facilitates the Extinction of Conditioned Fear in Humans. Biological Psychiatry, 78, 194-202.
https://doi.org/10.1016/j.biopsych.2014.10.015 |
| [30] | Chini, B., Leonzino, M., Leonzino, M., Braida, D. and Sala, M. (2014) Learning about Oxytocin: Pharmacologic and Behavioral Issues. Biological Psychiatry, 76, 360-366. https://doi.org/10.1016/j.biopsych.2013.08.029 |
| [31] | Acheson, D.T., Feifel, D., de Wilde, S., de Wilde, S., McKinney, R., Mckinney, R., Lohr, J.B. and Risbrough, V.B. (2013) The Effect of Intranasal Oxytocin Treatment on Conditioned Fear Extinction and Recall in a Healthy Human Sample. Psychopharmacology, 229, 199-208. https://doi.org/10.1007/s00213-013-3099-4 |
| [32] | Bertoni, A., Schaller, F., Tyzio, R., Gaillard, S., Santini, F., Xolin, M., Diabira, D., et al. (2021) Oxytocin Administration in Neonates Shapes the Hippocampal Circuitry and Restores Social Behavior in a Mouse Model of Autism. BioRxiv.
https://doi.org/10.1101/2020.09.21.306217 |
| [33] | Froemke, R.C. and Young, L.J. (2021) Oxytocin, Neural Plasticity, and Social Behavior. Annual Review of Neuroscience, 44, 359-381.
https://doi.org/10.1146/annurev-neuro-102320-102847 |
| [34] | Tomizawa, K., Iga, N., Lu, Y.F., Moriwaki, A., Matsushita, M., Li, S.T., et al. (2003) Oxytocin Improves Long-Lasting Spatial Memory during Motherhood through MAP Kinase Cascade. Nature Neuroscience, 6, 384-390.
https://doi.org/10.1038/nn1023 |
| [35] | Wu, Z.H., Xie, C.N., Kuang, H.X., Wu, J., Chen, X., Liu, H.B., Liu, T., et al. (2021) Oxytocin Mediates Neuroprotection against Hypoxic-Ischemic Injury in Hippocampal CA1 Neuron of Neonatal Rats. Neuropharmacology, 187, Article ID: 108488. |
| [36] | Sophie Knobloch, H., Charlet, A., Hoffmann, L.C., Eliava, M., Khrulev, S., Cetin, A., Osten, P., et al. (2012) Evoked Axonal Oxytocin Release in the Central Amygdala Attenuates Fear Response. Neuron, 73, 553-566.
https://doi.org/10.1016/j.neuron.2011.11.030 |
| [37] | Lee, S.Y., Park, S.H., Chung, C., Kim, J.J., Choi, S.Y., Choi, S.Y., Choi, S.Y., Han, J.S. and Han, J.S. (2015) Oxytocin Protects Hippocampal Memory and Plasticity from Uncontrollable Stress. Scientific Reports, 5, Article No. 18540. |
| [38] | Freda, S.N., Priest, M.F., Badong, D., Xiao, L., Liu, Y.J. and Kozorovitskiy, Y. (2022) Brainwide Input-Output Architecture of Paraventricular Oxytocin and Vasopressin Neurons. https://doi.org/10.1101/2022.01.17.476652 |
| [39] | Hoge, E.A., Anderson, E., Anderson, E.C., Anderson, E., Lawson, E.A., Bui, E., Fischer, L.E., Khadge, S.D., Barrett, L.F. and Simon, N.M. (2014) Gender Moderates the Effect of Oxytocin on Social Judgments. Human Psychopharmacology-Clinical and Experimental, 29, 299-304. |
| [40] | Ferguson, J.N., Matthew Aldag, J., Insel, T.R. and Young, L.J. (2001) Oxytocin in the Medial Amygdala Is Essential for Social Recognition in the Mouse. The Journal of Neuroscience, 21, 8278-8285.
https://doi.org/10.1523/JNEUROSCI.21-20-08278.2001 |
| [41] | Raam, T., McAvoy, K.M., Besnard, A., Veenema, A.H. and Sahay, A. (2017) Hippocampal Oxytocin Receptors Are Necessary for Discrimination of Social Stimuli. Nature Communications, 8, Article No. 2001.
https://doi.org/10.1038/s41467-017-02173-0 |
| [42] | Cilz, N.I., Cymerblit-Sabba, A., Cymerblit-Sabba, A. and Young, W.S. (2018) Oxytocin and Vasopressin in the Rodent Hippocampus. Genes, Brain and Behavior, 18, e12535. |
| [43] | Neumann, I.D. (2008) Brain Oxytocin: A Key Regulator of Emotional and Social Behaviours in Both Females and Males. Journal of Neuroendocrinology, 20, 858-865.
https://doi.org/10.1111/j.1365-2826.2008.01726.x |
| [44] | Labuschagne, I., Phan, K.L., Wood, A.G., Angstadt, M., Chua, P., Heinrichs, M., Stout, J.C. and Nathan, P.J. (2010) Oxytocin Attenuates Amygdala Reactivity to Fear in Generalized Social Anxiety Disorder. Neuropsychopharmacology, 35, 2403-2413.
https://doi.org/10.1038/npp.2010.123 |
| [45] | Kirsch, P., Esslinger, C., Chen, Q., Chen, Q., Chen, Q., Chen, Q., Mier, D., et al. (2005) Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans. The Journal of Neuroscience, 25, 11489-11493.
https://doi.org/10.1523/JNEUROSCI.3984-05.2005 |
| [46] | Burkett, J.P., Andari, E., Johnson, Z.V., Johnson, Z., Curry, D.C., de Waal, F.B.M. and Young, L.J. (2016) Oxytocin-Dependent Consolation Behavior in Rodents. Science, 351, 375-378. https://doi.org/10.1126/science.aac4785 |
| [47] | Domes, G., Lischke, A., Lischke, A., Berger, C., Grossmann, A., Hauenstein, K., Heinrichs, M. and Herpertz, S.C. (2010) Effects of Intranasal Oxytocin on Emotional Face Processing in Women. Psychoneuroendocrinology, 35, 83-93.
https://doi.org/10.1016/j.psyneuen.2009.06.016 |
| [48] | László, K., Kovács, A., Zagorácz, O., Ollmann, T., Péczely, L., Kertes, E., Lacy, D.G. and Lénárd, L. (2016) Positive Reinforcing Effect of Oxytocin Microinjection in the Rat Central Nucleus of Amygdala. Behavioural Brain Research, 296, 279-285.
https://doi.org/10.1016/j.bbr.2015.09.021 |
| [49] | Sarnyai, Z. and Kovács, G.L. (2014) Oxytocin in Learning and Addiction: From Early Discoveries to the Present. Pharmacology, Biochemistry and Behavior, 119, 3-9. https://doi.org/10.1016/j.pbb.2013.11.019 |
| [50] | Cox, B.M., Bentzley, B.S., Regen-Tuero, H., See, R.E., See, R.E., Reichel, C.M. and Aston-Jones, G. (2017) Oxytocin Acts in Nucleus Accumbens to Attenuate Methamphetamine Seeking and Demand. Biological Psychiatry, 81, 949-958. |
| [51] | Lee, H.C., Jang, M.J. and Noh, J. (2017) Oxytocin Attenuates Aversive Response to Nicotine and Anxiety-like Behavior in Adolescent Rats. Neuroscience Research, 115, 29-36. |
| [52] | Fan, X.Y., Shi, G. and Zhao, P. (2019) Reversal of Oxycodone Conditioned Place Preference by Oxytocin: Promoting Global DNA Methylation in the Hippocampus. Neuropharmacology, 160, Article ID: 107778.
https://doi.org/10.1016/j.neuropharm.2019.107778 |
| [53] | Che, X.H., Cai, J.L., Liu, Y.Y., Xu, T.Y., Yang, J.Y. and Wu, C.F. (2021) Oxytocin Signaling in the Treatment of Drug Addiction: Therapeutic Opportunities and Challenges. Pharmacology & Therapeutics, 223, Article ID: 107820. |
| [54] | Hollander, E., Bartz, J.A., Chaplin, W.F., Phillips, A.T., Sumner, J.A., Soorya, L., Anagnostou, E. and Wasserman, S. (2007) Oxytocin Increases Retention of Social Cognition in Autism. Biological Psychiatry, 61, 498-503.
https://doi.org/10.1016/j.biopsych.2006.05.030 |
| [55] | Popik, P., Vetulani, J. and van Ree, J.M. (1992) Low Doses of Oxytocin Facilitate Social Recognition in Rats. Psychopharmacology, 106, 71-74.
https://doi.org/10.1007/BF02253591 |
| [56] | Ross, H.E. and Young, L.J. (2009) Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior. Frontiers in Neuroendocrinology, 30, 534-547. |
| [57] | Bartz, J.A., Zaki, J., Bolger, N., Hollander, E., Ludwig, N., Ludwig, N.N., Kolevzon, A. and Ochsner, K.N. (2010) Oxytocin Selectively Improves Empathic Accuracy. Psychological Science, 4, 1042-1048. |
| [58] | Martins, D., Lockwood, P., Cutler, J., Moran, R. and Paloyelis, Y. (2022) Oxytocin Modulates Neurocomputational Mechanisms Underlying Prosocial Reinforcement Learning. Progress in Neurobiology, 213, Article ID: 102253.
https://doi.org/10.1016/j.pneurobio.2022.102253 |
| [59] | Donaldson, Z.R. and Young, L.J. (2008) Oxytocin, Vasopressin, and the Neurogenetics of Sociality. Science, 322, 900-904. https://doi.org/10.1126/science.1158668 |
| [60] | Ditzen, B., Schaer, M., Gabriel, B., Bodenmann, G., Ehlert, U. and Heinrichs, M. (2009) Intranasal Oxytocin Increases Positive Communication and Reduces Cortisol Levels during Couple Conflict. Biological Psychiatry, 65, 728-731.
https://doi.org/10.1016/j.biopsych.2008.10.011 |
| [61] | Inada, K., Hagihara, M., Tsujimoto, K., Abe, T., Konno, A., Hirai, H., Kiyonari, H. and Miyamichi, K. (2022) Plasticity of Neural Connections Underlying Oxytocin-Mediated Parental Behaviors of Male Mice.
https://doi.org/10.1101/2021.10.20.465207 |
| [62] | Shamay-Tsoory, S.G. and Abu-Akel, A. (2016) The Social Salience Hypothesis of Oxytocin. Biological Psychiatry, 79, 194-202.
https://doi.org/10.1016/j.biopsych.2015.07.020 |
| [63] | Gamer, M., Zurowski, B., Zurowski, B., Zurowski, B. and Büchel, C. (2010) Different Amygdala Subregions Mediate Valence-Related and Attentional Effects of Oxytocin in Humans. Proceedings of the National Academy of Sciences of the United States of America, 107, 9400-9405. https://doi.org/10.1073/pnas.1000985107 |
| [64] | Pincus, D., Kose, S., Arana, A., Johnson, K.A., Johnson, K.B., Morgan, P.S., Borckardt, J.J., et al. (2010) Inverse Effects of Oxytocin on Attributing Mental Activity to Others in Depressed and Healthy Subjects: A Double-Blind Placebo Controlled FMRI Study. Frontiers in Psychiatry, 1, Article 2235.
https://doi.org/10.3389/fpsyt.2010.00134 |
| [65] | Windle, R., Shanks, N., Lightman, S.L. and Ingram, C.D. (1997) Central Oxytocin Administration Reduces Stress-Induced Corticosterone Release and Anxiety Behavior in Rats. Endocrinology, 138, 2829-2834.
https://doi.org/10.1210/endo.138.7.5255 |
| [66] | Heinrichs, M., Baumgartner, T., Kirschbaum, C. and Ehlert, U. (2003) Social Support and Oxytocin Interact to Suppress Cortisol and Subjective Responses to Psychosocial Stress. Biological Psychiatry, 54, 1389-1398.
https://doi.org/10.1016/S0006-3223(03)00465-7 |
| [67] | Domes, G., Heinrichs, M., Gläscher, J., Büchel, C., Büchel, C., Büchel, C., Braus, D.F. and Herpertz, S.C. (2007) Oxytocin Attenuates Amygdala Responses to Emotional Faces Regardless of Valence. Biological Psychiatry, 62, 1187-1190.
https://doi.org/10.1016/j.biopsych.2007.03.025 |
| [68] | Takayanagi, Y., Yoshida, M., Bielsky, I.F., Ross, H.E., Kawamata, M., Onaka, T., et al. (2005) Pervasive Social Deficits, but Normal Parturition, in Oxytocin Receptor-Deficient Mice. Proceedings of the National Academy of Sciences of the United States of America, 102, 16096-16101. https://doi.org/10.1073/pnas.0505312102 |
| [69] | Carter, C.S. (2007) Sex Differences in Oxytocin and Vasopressin: Implications for Autism Spectrum Disorders? Behavioural Brain Research, 176, 170-186.
https://doi.org/10.1016/j.bbr.2006.08.025 |
| [70] | Guastella, A.J., Einfeld, S.L., Gray, K.M., Rinehart, N.J., Tonge, B.J., Lambert, T. and Hickie, I.B. (2010) Intranasal Oxytocin Improves Emotion Recognition for Youth with Autism Spectrum Disorders. Biological Psychiatry, 67, 692-694.
https://doi.org/10.1016/j.biopsych.2009.09.020 |
| [71] | Wu, S.P., Jia, M.X., Ruan, Y., Liu, J., Liu, J., Liu, J., Guo, Y.Q., et al. (2005) Positive Association of the Oxytocin Receptor Gene (OXTR) with Autism in the Chinese Han Population. Biological Psychiatry, 58, 74-77. |
| [72] | Andari, E., Duhamel, J.R., Zalla, T., Herbrecht, E., Leboyer, M. and Sirigu, A. (2010) Promoting Social Behavior with Oxytocin in High-Functioning Autism Spectrum Disorders. Proceedings of the National Academy of Sciences of the United States of America, 107, 4389-4394. https://doi.org/10.1073/pnas.0910249107 |
| [73] | Kasahara, Y., Onaka, T., Takahashi, N., Kawada, T. and Nishimori, K. (2008) Oxytocin Receptor-Deficient Mice Developed Late-Onset Obesity. Neuroreport, 19, 951-955. |
| [74] | Lawson, E.A., Marengi, D.A., DeSanti, R., Holmes, T.M., Schoenfeld, D.A. and Tolley, C. (2015) Oxytocin Reduces Caloric Intake in Men. Obesity, 23, 950-956.
https://doi.org/10.1002/oby.21069 |
| [75] | Arletti, R., Benelli, A. and Bertolini, A. (1989) Influence of Oxytocin on Feeding Behavior in the Rat. Peptides, 10, 89-93.
https://doi.org/10.1016/0196-9781(89)90082-X |
| [76] | Schulze, L., Lischke, A., Lischke, A., Greif, J., Herpertz, S.C., Heinrichs, M. and Domes, G. (2011) Oxytocin Increases Recognition of Masked Emotional Faces. Psychoneuroendocrinology, 36, 1378-1382.
https://doi.org/10.1016/j.psyneuen.2011.03.011 |
| [77] | Leknes, S., Wessberg, J., Wessberg, J., Ellingsen, D.M., Chelnokova, O., Olausson, H. and Laeng, B. (2013) Oxytocin Enhances Pupil Dilation and Sensitivity to ‘Hidden’ Emotional Expressions. Social Cognitive and Affective Neuroscience, 8, 741-749.
https://doi.org/10.1093/scan/nss062 |
| [78] | Graustella, A.J. and MacLeod, C. (2012) A Critical Review of the Influence of Oxytocin Nasal Spray on Social Cognition in Humans: Evidence and Future Directions. Hormones and Behavior, 61, 410-418. https://doi.org/10.1016/j.yhbeh.2012.01.002 |
| [79] | MacDonald, E., Dadds, M.R., Brennan, J., Williams, K., Levy, F. and Cauchi, A. (2011) A Review of Safety, Side-Effects and Subjective Reactions to Intranasal Oxytocin in Human Research. Psychoneuroendocrinology, 36, 1114-1126.
https://doi.org/10.1016/j.psyneuen.2011.02.015 |
| [80] | Modi, M.E., Connor-Stroud, F., Landgraf, R., Young, L.J. and Parr, L.A. (2014) Aerosolized Oxytocin Increases Cerebrospinal Fluid Oxytocin in Rhesus Macaques. Psychoneuroendocrinology, 45, 49-57.
https://doi.org/10.1016/j.psyneuen.2014.02.011 |
| [81] | Bradley, E.R. and Woolley, J.D. (2017) Oxytocin Effects in Schizophrenia: Reconciling Mixed Findings and Moving Forward. Neuroscience & Biobehavioral Reviews, 80, 36-56. https://doi.org/10.1016/j.neubiorev.2017.05.007 |
| [82] | Bradley, E.R., van Nieuwenhuizen, A., Abram, S.V., Abram, S., Niles, A.N. and Woolley, J.D. (2019) Oxytocin Does Not Improve Working Memory in Schizophrenia. Schizophrenia Research, 208, 486-487.
https://doi.org/10.1016/j.schres.2019.01.020 |
