Objectives: Therapeutic compliance can be defined as the degree of adequacy between
a patient’s behaviour and his doctor’s recommendations. Non-adherence to treatment has serious consequences in terms of morbidity and
mortality. Our aim was to assess adherence among patients treated for chronic
inflammatory rheumatism in Lomé. Patients and Methods: This was a
multicentre cross-sectional study conducted from January 2015 to December 2021.
Patients aged 18 years or older, treated in the rheumatology departments of the
Sylvanus Olympio University Hospital or the Bè Hospital during the study
period, were included if they were diagnosed with chronic inflammatory
rheumatism and started on disease-modifying therapy. Adherence was assessed
using the Compliance Questionnaire Rheumatology 19 questionnaire, with a
threshold for good compliance set at 80%. Results: Out of 13,214
patients received, 159 suffered from chronic inflammatory rheumatism (hospital
frequency 1.5%), and 60 met the inclusion criteria for our study. There were 55
women (91.7%) and 5 men (8.3%), giving a sex-ratio of 1/11. The mean age was
49.5 ± 13.5 years (extremes: 19 and 78 years). Rheumatoid arthritis (68.3%) was
the most common rheumatic disease, followed by undefined rheumatic diseases
(16.6%) and spondyloarthritis (8.3%). Average compliance with treatment was
76.9% ± 12.4% (extremes 29.8 and 91.2). There was no statistically significant
difference according to the type of rheumatism. Conclusion: Overall
compliance was poor, with a Compliance Questionnaire Rheumatology 19 of less
than 80%. It was non-significantly influenced by socioeconomic status, disease
severity and duration of progression.
References
[1]
Desbrus-Qochih, A. and Cathédras, P. (2012) Obéir ou adhérer? L’observance thérapeutique en question. Médecine & Longévité, 4, 111-122. https://doi.org/10.1016/j.mlong.2012.09.001
[2]
Tuncay, R., Eksioglu, E., Cakir, B., Gurcay, E. and Cakci, A. (2007) Factors Affecting Drug Treatment Compliance in Patients with Rheumatoid Arthritis. Rheumatology International, 27, 743-746. https://doi.org/10.1007/s00296-006-0299-9
[3]
Salt, E. and Frazier, S. (2010) Adherence to Disease-Modifying Antirheumatic Drugs in Rheumatoid Arthritis Patients: A Narrative Review of the Literature. Orthopaedic Nursing, 29, 260-275. https://doi.org/10.1097/NOR.0b013e3181e5c2c9
[4]
Scheen, A.J. and Giet, D. (2010) Non-Observance Thérapeutique: Causes, Conséquences et solutions. Revue Médicale de Liège, 65, 239-245.
[5]
Kedra, J. and Gossec, L. (2016) L’observance des traitements dans les rhumatismes inflammatoires chroniques. La Lettre du Rhumatologue, 424, 32-35.
[6]
World Health Organization (2003) Adherence to Long-Term Therapies. Evidence for Action. https://iris.who.int/bitstream/handle/10665/42682/9?sequence=1
[7]
Amor, B., Dougados, M. and Mijiyawa, M. (1990) Critères diagnostiques des spondylarthropathies. Revue du Rhumatisme, 57, 85-89.
[8]
Hua, C. and Combe, B. (2017) Les nouveaux critères de classification ACR/EULAR 2010 pour un diagnostic plus précoce de la polyarthrite rhumatoide. Revue du Rhumatisme Monographies, 84, 337-342. https://doi.org/10.1016/j.monrhu.2017.07.001
[9]
Meyer, O. (2010) Lupus et syndrome des anticorps antiphospholipides. Critères de diagnostic et de suivi. Revue du Rhumatisme Monographies, 77, 82-88. https://doi.org/10.1016/j.monrhu.2010.02.006
[10]
Elhai, M., Avouac, J., Kahan, A. and Allanore, Y. (2015) Sclérodermie systémique: Progrès récents. Revue du Rhumatisme, 82, 291-297. https://doi.org/10.1016/j.rhum.2015.04.007
[11]
Job-Deslandre, C. (2013) Comment faire le diagnostic d’arthrite juvénile idiopathique? La Lettre du Rhumatologue, 394, 26-29.
[12]
Graf, L. and Geiser, T. (2018) La Sarcoïdose. Forum Médical Suisse, 18, 695-701. https://doi.org/10.4414/fms.2018.03347
[13]
De Klerk, E., Van der Heijde, D., Landewé, R., van der Tempel, H. and van der Linden, S. (2003) The Compliance-Questionnaire-Rheumatology Compared with Electronic Medication Event Monitoring: A Validation Study. The Journal of Rheumatology, 30, 2469-2475.
[14]
Kakpovi, K., Oniankitan, S., Tagbor, K.C., Kondian, K., Koffi-Tessio, V.E.S., Atake, A.E., et al. (2021) Rhumatismes inflammatoires chroniques en consultation rhumatologique à Lomé (Togo). Rhumatologie Afrique Francophone, 1, 16-23.
[15]
Kamissoko, A.B., Diallo, M.L., Oniankitan, S., Baldé, N., Traoré, M., Yombouno, E., et al. (2020) Prise en charge des rhumatismes inflammatoires chroniques en Guinée. Journal de la Recherche Scientifique de l’Université de Lomé, 22, 137-144.
[16]
Betegnie, A.-L. (2013) Adhésion médicamenteuse et représentations des patients atteints de rhumatisme inflammatoire chronique sous biothérapie. Etude ADEP’RI. M.D. Dissertation Grenoble, University Joseph Fournier, Grenoble. https://dumas.ccsd.cnrs.fr/dumas-01242050
[17]
Kaboré, F., Zabsonre Tiendrebeogo, W.J.S., Sougué, C., Zombré, D.M.A.F., Sompougdou, C., Ouédraogo, M., et al. (2021) Panorama des rhumatismes inflammatoires chroniques au Burkina Faso: Bilan de 14 ans de pratique de la rhumatologie. Revue du Rhumatisme, 88, A318-A319. https://doi.org/10.1016/j.rhum.2021.10.549
[18]
Kakpovi, K., Koffi-Tessio, V.E.S., Houzou, P., Fianyo, E., Kolou, M., Kueviakoe, M.I., et al. (2017) Profil de la polyarthrite rhumatoïde en consultation rhumatologique à Lomé (Togo). European Scientific Journal, 13, 125-132. https://doi.org/10.19044/esj.2017.v13n24p267
[19]
Fianyo, E., Kakpovi, K., Houzou, P., Amouzou, Y., Koffi-Tessio, V.E.S., Tagbor, K.C., et al. (2019) Self-Medication in Rheumatology in Lomé (Togo). Journal de la Recherche Scientifique de l’Université de Lomé, 21, 115-119.
[20]
Arturi, P., Schneeberger, E.E., Sommerfleck, F., Buschiazzo, E., Ledesma, C., Maldonado Cocco, J.A., et al. (2013) Adherence to Treatment in Patients with Ankylosing Spondylitis. Clinical Rheumatology, 32, 1007-1015. https://doi.org/10.1007/s10067-013-2221-7
[21]
Waimann, C.A., Marengo, M.F, de Achaval, S., Cox, V.L., Garcia-Gonzalez, A., Reveille, J.D., et al. (2013) Electronic Monitoring of Oral Therapies in Ethnically Diverse and Economically Disadvantaged Patients with Rheumatoid Arthritis: Consequences of Low Adherence. Arthritis & Rheumatology, 65, 1421-1429. https://doi.org/10.1002/art.37917
[22]
van den Bemt, B.J., van den Hoogen, F.H., Benraad, B., Hekster, Y.A., van Riel, P.L. and van Lankveld, W. (2009) Adherence Rates and Associations with Nonadherence in Patients with Rheumatoid Arthritis Using Disease Modifying Antirheumatic Drugs. The Journal of Rheumatology, 36, 2164-2170. https://doi.org/10.3899/jrheum.081204