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多囊卵巢综合征及干预措施对妊娠结局和子代的影响
The Effect of Polycystic Ovary Syndrome and Its Intervention Measures on Pregnancy Outcomes and Offspring

DOI: 10.12677/ACM.2024.141030, PP. 204-210

Keywords: 多囊卵巢综合征,产科并发症,子代,干预措施
Polycystic Ovary Syndrome
, Obstetric Complications, Offspring, Intervention Measures

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Abstract:

多囊卵巢综合征是育龄期女性最常见的生殖内分泌疾病之一,临床表现具有高度异质性,主要为内分泌代谢紊乱导致的卵泡发育异常,不仅会增加孕期各种并发症的风险,甚至会影响胎儿生长发育,导致不良产科结局,部分患者其子代还会表现出远期精神及内分泌等方面的改变。本文主要从母体PCOS对妊娠结局及其子代造成的影响,以及针对多囊卵巢综合征所采取的干预措施对妊娠结局和子代产生的影响进行阐述。
Polycystic ovary syndrome (PCOS) is one of the most common reproductive endocrine diseases in women of reproductive age. Its clinical manifestations are highly heterogeneous, mainly due to ab-normal follicle development caused by endocrine and metabolic disorders, which will not only in-crease the risk of various complications during pregnancy, but also affect fetal growth and devel-opment, leading to adverse obstetric outcomes. Some of the offspring of patients will also show long-term mental and endocrine changes. This article mainly discusses the influence of maternal PCOS on pregnancy outcome and offspring, and the influence of intervention measures for PCOS on pregnancy outcome and offspring.

References

[1]  Yildiz, B.O., Bozdag, G., Yapici, Z., Esinler, I. and Yarali, H. (2012) Prevalence, Phenotype and Cardiometabolic Risk of Polycystic Ovary Syndrome under Different Diagnostic Criteria. Human Reproduction, 27, 3067-3073.
https://doi.org/10.1093/humrep/des232
[2]  Siddiqui, S., Mateen, S., Ahmad, R. and Moin, S. (2022) A Brief In-sight into the Etiology, Genetics, and Immunology of Polycystic Ovarian Syndrome (PCOS). Journal of Assisted Re-production and Genetics, 39, 2439-2473.
https://doi.org/10.1007/s10815-022-02625-7
[3]  Saez, J.M., Forest, M.G., Morera, A.M. and Bertrand, J. (1972) Metabolic Clearance Rate and Blood Production Rate of Testosterone and Dihydrotestosterone in Normal Subjects, dur-ing Pregnancy, and in Hyperthyroidism. Journal of Clinical Investigation, 51, 1226-1234.
https://doi.org/10.1172/JCI106917
[4]  Sir-Petermann, T., Maliqueo, M., Angel, B., Lara, H.E., Pérez-Bravo, F. and Recabarren, S.E. (2002) Maternal Serum Androgens in Pregnant Women with Polycystic Ovarian Syndrome: Possi-ble Implications in Prenatal Androgenization. Human Reproduction, 17, 2573-2579.
https://doi.org/10.1093/humrep/17.10.2573
[5]  陈志燕, 金力. 多囊卵巢综合征的高雄激素血症对生育的影响[J]. 中华妇产科杂志, 2019, 54(6): 425-428.
https://doi.org/10.3760/cma.j.issn.0529-567x.2019.06.014
[6]  Gur, E.B., Karadeniz, M. and Turan, G.A. (2015) Fetal Programming of Polycystic Ovary Syndrome. World Journal of Diabetes, 6, 936-942.
https://doi.org/10.4239/wjd.v6.i7.936
[7]  康媛, 李笑天. 成人疾病的胎儿起源[J]. 国外医学(妇产科学分册), 2007, 34(5): 298-301.
[8]  Lapehn, S. and Paquette, A.G. (2022) The Placental Epigenome as a Molecular Link Be-tween Prenatal Exposures and Fetal Health Outcomes through the DOHaD Hypothesis. Current Environmental Health Reports, 9, 490-501.
https://doi.org/10.1007/s40572-022-00354-8
[9]  Sulyok, E., Farkas, B. and Bodis, J. (2023) Pathomechanisms of Prenatally Programmed Adult Diseases. Antioxidants, 12, Article 1354.
https://doi.org/10.3390/antiox12071354
[10]  Frasch, M.G., Yoon, B.J., Helbing, D.L., Snir, G., Antonelli, M.C. and Bauer, R. (2023) Autism Spectrum Disorder: A Neuro-Immunometabolic Hypothesis of the Developmental Origins. Biology, 12, Article 914.
https://doi.org/10.3390/biology12070914
[11]  Anderson, H., Fogel, N., Grebe, S.K., Singh, R.J., Taylor, R.L. and Dunaif, A. (2010) Infants of Women with Polycystic Ovary Syndrome Have Lower Cord Blood Androstenedione and Estradiol Levels. The Journal of Clinical Endocrinology & Metabolism, 95, 2180-2186.
https://doi.org/10.1210/jc.2009-2651
[12]  Cena, H., Chiovato, L. and Nappi, R.E. (2020) Obesity, Polycystic Ova-ry Syndrome, and Infertility: A New Avenue for GLP-1 Receptor Agonists. The Journal of Clinical Endocrinology & Metabolism, 105, e2695-e2709.
https://doi.org/10.1210/clinem/dgaa285
[13]  Guo, F., Huang, Y., Fernando, T. and Shi, Y. (2022) Altered Molecu-lar Pathways and Biomarkers of Endometrial Receptivity in Infertile Women with Polycystic Ovary Syndrome. Repro-ductive Sciences, 29, 3335-3345.
https://doi.org/10.1007/s43032-022-00845-x
[14]  Azziz, R. (2002) Polycystic Ovary Syndrome, Insulin Resistance, and Molecular Defects of Insulin Signaling. The Journal of Clinical Endocrinology & Metabolism, 87, 4085-4087.
https://doi.org/10.1210/jc.2002-021131
[15]  Ujvari, D., Jakson, I., Oldmark, C., Attarha, S., Alkasalias, T., Sala-mon, D., Gidl?f, S. and Hirschberg, A.L. (2018) Prokineticin 1 Is Up-Regulated by Insulin in Decidualizing Human En-dometrial Stromal Cells. Journal of Cellular and Molecular Medicine, 22, 163-172.
https://doi.org/10.1111/jcmm.13305
[16]  Shan, H., Luo, R., Guo, X., Li, R., Ye, Z., Peng, T., Liu, F. and Yang, Z. (2022) Abnormal Endometrial Receptivity and Oxidative Stress in Polycystic Ovary Syndrome. Frontiers in Pharma-cology, 13, Article 904942.
https://doi.org/10.3389/fphar.2022.904942
[17]  Asanidze, E., Kristesashvili, J. and Andguladze, S. (2019) Correla-tion between Levels of Homocysteine, Anti-Mullerian Hormone and Insulin Resistance in PCOS Patient with Recurrent Miscarriage. Georgian Medical News, 290, 25-29.
[18]  Li, R., Zhang, Q.F., Yang, D.Z., Li, S.W., Lu, S.L., Wu, X.K., Wei, Z.L., Song, X.R., Wang, X.X., Fu, S.X., Lin, J.F., Zhu, Y.M., Jiang, Y., Feng, H.L. and Qiao, J. (2013) Prevalence of Polycystic Ovary Syndrome in Women in China: A Large Community-Based Study. Human Reproduction, 28, 2562-2569.
https://doi.org/10.1093/humrep/det262
[19]  Asanidze, E., Kristesashvili, J. and Andguladze, S. (2019) Correlation between Levels of Homocysteine, Anti-Müllerian Hormone and Insulin Resistance in Pcos Patients with Re-current Miscarriage. Georgian Medical News, 290, 25-29.
[20]  Broughton, D.E. and Moley, K.H. (2017) Obesity and Female Infertility: Potential Mediators of Obesity’s Impact. Fertility and Sterility, 107, 840-847.
https://doi.org/10.1016/j.fertnstert.2017.01.017
[21]  Palomba, S., de Wilde, M.A., Falbo, A., Koster, M.P.H., La Sala, G.B. and Fauser, B.C.J.M. (2015) Pregnancy Complications in Women with Polycystic Ovary Syndrome. Human Reproduction Update, 21, 575-592.
https://doi.org/10.1093/humupd/dmv029
[22]  Hart, R. (2019) Generational Health Impact of PCOS on Women and Their Children. Medical Sciences, 7, Article 49.
https://doi.org/10.3390/medsci7030049
[23]  Taylor, E.B. and Sasser, J.M. (2017) Natural Killer Cells and T Lym-phocytes in Pregnancy and Pre-Eclampsia. Clinical Science, 131, 2911-2917.
https://doi.org/10.1042/CS20171070
[24]  Boomsma, C.M., Eijkemans, M.J.C., Hughes, E.G., et al. (2006) A Me-ta-Analysis of Pregnancy Outcomes in Women with Polycystic Ovary Syndrome. Human Reproduction Update, 12, 673-683.
https://doi.org/10.1093/humupd/dml036
[25]  Thagaard, I.N., Krebs, L., Holm, J.C., et al. (2017) Adi-ponectin and Leptin as First Trimester Markers for Gestational Diabetes Mellitus: A Cohort Study. Clinical Chemistry and Laboratory Medicine (CCLM), 55, 1805-1812.
https://doi.org/10.1515/cclm-2017-0427
[26]  Wang, T., Fu, H., Chen, L., et al. (2017) Pregnancy Complication among Women with Polycystic Ovary Syndrome in China: A Meta-Analysis. Journal of Central South University, 42, 1300-1310.
[27]  邢彦, 祁秀娟, 王瑞静. 高雄激素对大鼠胎盘P450芳香化酶表达的影响[J]. 现代生物医学进展, 2010, 10(19): 3635-3638.
[28]  Puttabyatappa, M., Cardoso, R.C. and Padmanabhan, V. (2016) Effect of Maternal PCOS and PCOS-Like Phenotype on the Offspring’s Health. Molecular and Cellular Endocrinology, 435, 29-39.
https://doi.org/10.1016/j.mce.2015.11.030
[29]  Barrett, E.S., Hoeger, K.M., Sathyanarayana, S., Abbott, D.H., Redmon, J.B., Nguyen, R.H.N. and Swan, S.H. (2018) Anogenital Distance in Newborn Daughters of Women with Polycystic Ovary Syndrome Indicates Fetal Testosterone Exposure. Journal of Developmental Origins of Health and Disease, 9, 307-314.
https://doi.org/10.1017/S2040174417001118
[30]  Halici-Ozturk, F., Yucel Yetiskin, F.D., Gurlek, B., Ocal, F.D., Yakut, K., Engin-Ustun, Y., Celen, S. and Sahin, D. (2023) Longer Anogenital Distance in Female Fetus of Diabetic and Obese Pregnant Women. Taiwanese Journal of Obstetrics and Gynecology, 62, 530-536.
https://doi.org/10.1016/j.tjog.2023.02.005
[31]  Sir-Petermann, T., Codner, E., Perez, V., Echiburu, B., Maliqueo, M., Ladron de Guevara, A., Preisler, J., Crisosto, N., Sanchez, F., Cassorla, F. and Bhasin, S. (2009) Metabolic and Re-productive Features before and during Puberty in Daughters of Women with Polycystic Ovary Syndrome. The Journal of Clinical Endocrinology & Metabolism, 94, 1923-1930.
https://doi.org/10.1210/jc.2008-2836
[32]  李琴华, 彭艳, 吴效科, 侯丽辉, Elisabet Stener Victorin. 孕期高雄大鼠子代实验性多囊卵巢综合征模型构建[J].科技导报, 2008, 26(12): 28-33.
[33]  石秀红, 郑莲钦, 林秀, 黄婴平. 妊娠期糖尿病对新生儿胆红素的影响[J]. 糖尿病新世界, 2017, 20(5): 22-23.
[34]  唐枭雄, 雷亚松, 刘震寰. 血脂紊乱对妊娠期糖尿病患者胰岛素抵抗的影响[J]. 医药论坛杂志, 2021, 42(10): 24-26, 30.
[35]  应红安, 黄子扬, 王振华, 程恩华, 许海英, 洪卫文, 梁小珍. 宫内慢性缺氧致子代大鼠成年后胰岛素抵抗和高血压[J]. 中华高血压杂志, 2021, 29(5): 434-443.
[36]  Chura, L.R., Lombardo, M.V., Ashwin, E., Auyeung, B., Chakrabarti, B., Bullmore, E.T. and Baron-Cohen, S. (2010) Organizational Effects of Fetal Testosterone on Human Corpus Callosum Size and Asymmetry. Psychoneuroendocrinology, 35, 122-132.
https://doi.org/10.1016/j.psyneuen.2009.09.009
[37]  Bilbo, S.D. and Tsang, V. (2010) Enduring Consequences of Maternal Obesity for Brain Inflammation and Behavior of Offspring. FASEB Journal, 24, 2104-2115.
https://doi.org/10.1096/fj.09-144014
[38]  Teede, H.J., Misso, M.L., Costello, M.F., Dokras, A., Laven, J., Moran, L., Piltonen, T. and Norman, R.J. (2018) International PCOS Network. Recommendations from the International Evi-dence-Based Guideline for the Assessment and Management of Polycystic Ovary Syndrome. Fertility and Sterility, 110, 364-379.
[39]  Zhu, D., Chen, Y., Huang, J., Deng, H., Shen, X., Lu, D. and Xu, L. (2022) Effects of Metformin on Pregnancy Outcome, Metabolic Profile, and Sex Hormone Levels in Women with Polycystic Ovary Syndrome and Their Offspring: A Systematic Review and Meta-Analysis. Annals of Translational Medicine, 10, Article 418.
https://doi.org/10.21037/atm-22-909
[40]  Seli, E. and Duleba, A.J. (2004) Treatment of PCOS with Metformin and Other Insulin-Sensitizing Agents. Current Diabetes Reports, 4, 69-75.
https://doi.org/10.1007/s11892-004-0014-8
[41]  van Weelden, W., Wekker, V., de Wit, L., Limpens, J., Ij?s, H., van Wassenaer-Leemhuis, A.G., Roseboom, T.J., van Rijn, B.B., DeVries, J.H. and Painter, R.C. (2018) Long-Term Ef-fects of Oral Antidiabetic Drugs during Pregnancy on Offspring: A Systematic Review and Meta-Analysis of Follow-Up Studies of RCTs. Diabetes Therapy, 9, 1811-1829.
https://doi.org/10.1007/s13300-018-0479-0
[42]  Zhang, X., Miao, H., Zhou, J., Chen, Y., Ou, Y., Song, Y., Peng, X., Li, Y. and Li, L. (2023) Association between Preconception Anti-Androgen Therapy and Pregnancy Outcomes of Patients with PCOS: A Prospective Cohort Study. Frontiers in Endocrinology, 14, Article 1109861.
https://doi.org/10.3389/fendo.2023.1109861
[43]  陈敏. 分析达英-35配合促排卵法治疗多囊卵巢综合征不孕的效果及妊娠结局影响[J]. 系统医学, 2022, 7(8): 164-168.
[44]  江抒恬. 黄体期促排卵方案子代远期安全性的随访研究[D]: [博士学位论文]. 上海: 上海交通大学, 2018.
https://doi.org/10.27307/d.cnki.gsjtu.2018.003826
[45]  赵如凇. 来曲唑对人工授精子代体格和精神发育的影响[D]: [硕士学位论文]. 济南: 山东大学, 2018.

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