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Method Development and Validation of the Simultaneous Analysis of Methylisothiazolinone, Methylchloroisothiazolinone, Benzisothiazolinone and Bronopol in Washing-Up Liquid

DOI: 10.4236/ajac.2024.151003, PP. 43-55

Keywords: Preservatives, Analytical Validation, Methylisothiazolinone, Methylchloroisothiazolinone, Benzisothiazolinone, Bronopol, HPLC, Washing-Up Liquid

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Abstract:

A method of analysis for the simultaneous determination of methylisothiazolinone (MI), methylchloroisothiazolinone (CMI), benzisothiazolinone (BIT) and Bronopol (BNP) in washing-up liquid was established. The method consisted of a gradient HPLC analysis at three different wavelengths. The four compounds could be analyzed with good precision and accuracy.

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