Herein we report a patient with nephroblastoma which was successfully removed at the Sunyani Teaching Hospital CJ Oppong theatre in Ghana in sub-Saharan Africa by extended below umbilical incision. Our patient had a family history of Wilms tumour predisposing him to the disease. His main symptoms were haematuria and abdominal mass which was noticed later. Examination and investigation were suggestive of a late-stage unilateral Nephroblastoma resulting in the need for nephrectomy. To reduce the need for such radical surgeries among children at an early stage, there is the need for early screening of children for Wilms tumours especially, those with family predisposition as in our case study. The case report presented here constitutes a rare case of nephroblastoma in the literature.
References
[1]
Luu, D.T., et al. (2021) Wilms’ Tumor in Horseshoe Kidney. Case Reports in Nephrology and Dialysis, 11, 124-128. https://doi.org/10.1159/000514774
Huff, V. (2011) Wilms’ Tumours: About Tumour Suppressor Genes, an Oncogene and a Chameleon Gene. Nature Reviews Cancer, 11, 111-121. https://doi.org/10.1038/nrc3002
[4]
Tripathi, S., et al. (2021) Wilms’ Tumor in Adults—Conventional and Unconventional Presentations of a Rare Entity with a Review of Literature. Journal of Kidney Cancer and VHL, 8, 40-48. https://doi.org/10.15586/jkcvhl.v8i2.186
[5]
Hol, J.A., et al. (2021) Clinical Characteristics and Outcomes of Children with WAGR Syndrome and Wilms Tumor and/or Nephroblastomatosis: The 30-Year SIOP-RTSG Experience. Cancer, 127, 628-638. https://doi.org/10.1002/cncr.33304
[6]
Mussa, A., et al. (2019) The Effectiveness of Wilms Tumor Screening in Beckwith-Wiedemann Spectrum. Journal of Cancer Research and Clinical Oncology, 145, 3115-3123. https://doi.org/10.1007/s00432-019-03038-3
[7]
Nelson, M.V., et al. (2021) New Approaches to Risk Stratification for Wilms Tumour. Paediatrics, 33, 40-48. https://doi.org/10.1097/MOP.0000000000000988
Steur, A., et al. (2022) Characteristics and Outcome of Children with Wilms Tumor Requiring Intensive Care Admission in First Line Therapy. Cancers, 14, 943. https://doi.org/10.3390/cancers14040943
[10]
Groenendijk, A., et al. (2021) Prognostic Factors for Wilms Tumor Recurrence: A Review of the Literature. Cancers, 13, 3142. https://doi.org/10.3390/cancers13133142
[11]
Szymanska, A., et al. (2016) Wilms’ Tumor with Intra-Atrial Extension: Treatment and Management. World Journal for Pediatric and Congenital Heart Surgery, 7, 116-119. https://doi.org/10.1177/2150135115583728
[12]
Hong, B. and Dong, R. (2021) Research Advances in the Targeted Therapy and Immunotherapy of Wilms Tumor: A Narrative Review. Translational Cancer Research, 10, 1559-1567. https://doi.org/10.21037/tcr-20-3302
[13]
Bălănescu, R.N., et al. (2022) Role of Ultrasonography in the Diagnosis of Wilms’ Tumour. Children, 9, 1252. https://doi.org/10.3390/children9081252
[14]
Cunningham, M.E., et al. (2020) Global Disparities in Wilms Tumor. Journal of Surgical Research, 247, 34-51. https://doi.org/10.1016/j.jss.2019.10.044
[15]
Rutgers, J.J., et al. (2021) Interobserver Variability between Experienced and Inexperienced Observers in the Histopathological Analysis of Wilms Tumors: A Pilot Study for Future Algorithmic Approach. Diagnostic Pathology, 16, Article Number: 77. https://doi.org/10.1186/s13000-021-01136-w
[16]
Balis, F., et al. (2021) Wilms Tumor (Nephroblastoma), Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. Journal of the National Comprehensive Cancer Network, 19, 945-977. https://doi.org/10.6004/jnccn.2021.0037
