|
|
Medical Diagnosis 2024
原发性高血压治疗药物相关基因多态性的研究进展
|
Abstract:
原发性高血压是由遗传和环境两大因素综合影响的结果，这是一种由多个基因共同作用导致的遗传性疾病，现今通过药物来控制血压是主要的治疗和降低相关并发症的策略。然而，在临床实践中，降压药物之间的个体差异非常常见，这主要基于降血压药物代谢酶、受体及其他药物相关基因的突变差异。抗高血压药物基因多态性研究对于改进现有的药物和探索新的降压药物具有重要作用。本文对原发性高血压普遍的治疗药物相关基因多态性研究进展进行综述，为后续基于个体差异的原发性高血压患者的治疗提供精准的理论基础。
Essential hypertension is a combination of genetic and environmental factors, which is a genetic disease caused by multiple genes. At present, controlling blood pressure through drugs is the main treatment strategy and reducing related complications. However, in clinical practice, individual dif-ferences between blood pressure lowering drugs are very common, which is mainly based on dif-ferences in mutations of blood pressure lowering drug metabolizing enzymes, receptors and other drug-related genes. The study of gene polymorphism of antihypertensive drugs plays an important role in improving existing drugs and exploring new antihypertensive drugs. This article reviews the research progress of drug related gene polymorphism in the treatment of essential hypertension, which provides a theoretical basis for providing accurate treatment for essential hypertension pa-tients according to individual differences.
| [1] | Tu, J.F., Wang, L.Q., Liu, J.H., et al. (2021) Home-Based Transcutaneous Electrical Acupoint Stimulation for Hypertension: A Randomized Controlled Pilot Trial. Hypertension Research, 44, 1300.
https://doi.org/10.1038/s41440-021-00702-5 |
| [2] | 郑莉凡, 张振玉, 王秀芹. 动态心电图P波离散度和Tp-e间期联合血压变异性对原发性高血压患者室性心律失常易感性的预测效能[J]. 中国心血管病研究, 2023, 21(6): 538-543. |
| [3] | 张彦伟, 陈明远, 赵俊康. 山西省高血压病人降压药物相关基因多态性分布[J]. 护理研究, 2023, 37(9): 1656-1658. |
| [4] | Liu, J., Feng, D., Kan, X., et al. (2021) Polymorphisms in the CYP3A5 Gene Significantly Affect the Phar-macokinetics of Sirolimus after Kidney Transplantation. Pharmacogenomics, 22, 903-912.
https://doi.org/10.2217/pgs-2021-0083 |
| [5] | Galaviz-Hernández, C., Lazalde-Ramos, B.P., Lares-Assef, I., et al. (2020) Influence of Genetic Admixture Components on CYP3A5*3 Allele-Associated Hypertension in Amerindian Populations from Northwest Mexico. Frontiers in Pharmacology, 11, 638. https://doi.org/10.3389/fphar.2020.00638 |
| [6] | Liang, H., Zhang, X., Ma, Z., et al. (2021) Association of CYP3A5 Gene Polymorphisms and Amlodipine-Induced Peripheral Edema in Chinese Han Patients with Essential Hypertension. Pharmacogenomics and Personalized Medicine, 14, 189-197. https://doi.org/10.2147/PGPM.S291277 |
| [7] | 易天骄, 赵友云. CYP3A5、CYP2C9、AGTR1基因多态性对单药治疗原发性高血压疗效的影响研究[J]. 国际检验医学杂志, 2022, 43(13): 1607-1611. |
| [8] | Chan, S.W., Chu, T.T.W., Ho, C.S., Kong, A.P.S., Tomlinson, B. and Zeng, W. (2021) Influence of CYP2D6 and CYP3A5 Polymorphisms on the Pharmacokinet-ics and Pharmacodynamics of Bisoprolol in Hypertensive Chinese Patients. Frontiers in Medicine (Lausanne), 8, 683498. https://doi.org/10.3389/fmed.2021.683498 |
| [9] | 刘泽, 郝言, 张薇, 等. 肾上腺素β受体基因、G蛋白基因和CYP2D6基因多态性对美托洛尔导致脂代谢异常的影响[J]. 中国医院用药评价与分析, 2023, 23(6): 693-695+700. |
| [10] | 张晴. 基于多重PCR靶向捕获测序技术的中国汉族人群CYP2C9基因多态性研究[D]: [博士学位论文]. 北京: 北京协和医学院, 2023. |
| [11] | Chen, K., Xiao, P., Li, G., Wang, C. and Yang, C. (2021) Distributive Characteristics of the CYP2C9 and AGTR1 genetic Polymorphisms in Han Chinese Hypertensive Patients: A Retrospective Study. BMC Cardiovascular Disorders, 21, 73. https://doi.org/10.1186/s12872-021-01895-w |
| [12] | Dong, H., Wang, F.Z., Shi, K., et al. (2021) Association of Cyto-chrome P450 2C9*3 and Angiotensin II Receptor 1 (1166A>C) Gene Polymorphisms with the Antihypertensive Effect of Irbesartan. American Journal of Hypertension, 34, 121. https://doi.org/10.1093/ajh/hpaa134 |
| [13] | 喻晶, 杨璐, 张舒琼. 7 个高血压药物相关基因的多态性在582例汉族高血压患者中的分布[J]. 国际检验医学杂志, 2021, 42(3): 325-328, 333. |
| [14] | 沈鹃琴, 王林, 徐少坤, 等. ADRB_1基因多态性对高血压患者美托洛尔缓释片疗效的影响[J]. 心电与循环, 2023, 42(2): 145-148. |
| [15] | Chen, L., Xiao, T., Chen, L., Xie, S., Deng, M. and Wu, D. (2018) The Association of ADRB1 and CYP2D6 Polymorphisms with Antihypertensive Effects and Analysis of Their Contribution to Hypertension Risk. The American Journal of the Medical Sciences, 355, 235-239. https://doi.org/10.1016/j.amjms.2017.11.002 |
| [16] | Wang, Z., Hou, J., Zheng, H., et al. (2023) Genetic and Phenotypic Frequency Distribution of ACE, ADRB1, AGTR1, CYP2C9*3, CYP2D6*10, CYP3A5*3, NPPA and Factors Associated with Hypertension in Chinese Han hypertensive patients. Medicine (Baltimore), 102, e33206. https://doi.org/10.1097/MD.0000000000033206 |
| [17] | Goswamib, K.V. (2022) Angiotensin Converting Enzyme (ACE). Clinica Chimica Acta, 524, 113-122.
https://doi.org/10.1016/j.cca.2021.10.029 |
| [18] | 刘钢. ACE基因I/D多态性与云南纳西族人群高原低氧适应、高血压及血脂异常的相关性研究[D]: [硕士学位论文]. 大理: 大理大学, 2023. |
| [19] | Liu, M., Yi, J. and Tang, W. (2021) Associa-tion between Angiotensin Converting Enzyme Gene Polymorphism and Essential Hypertension: A Systematic Review and Me-ta-Analysis. Journal of the Renin-Angiotensin-Aldosterone System, 22, 1470320321995074. https://doi.org/10.1177/1470320321995074 |
