Objectives: To assess respiratory elastance and resistive
properties in patients with autoimmune liver disorders using the passive
relaxation expiration technique and compare findings to a group of patients
with non-autoimmune liver disease and control subjects. These findings were
then related to control of ventilation and gas exchange. A secondary objective
was to assess respiratory muscle strength and gas exchange and their relation
to respiratory mechanics. Methods: Measurements included respiratory
elastance and resistance using the passive relaxation method. Pulmonary
function, gas exchange and control of ventilation were assessed using standard
methods. Results: a) Compared to control subjects, Ers in patients with
liver disease was on average 50% greater than in controls; b) mean respiratory
resistance, expressed as the respiratory constants, K1 and K2 in the Rohrer relationship, Pao/V’ = K1 + K2V’, was not
different from control resistance; c) mean maximal inspiratory and maximal
expiratory pressures averaged 36% and 55% of their respective control values;
d) inspiratory occlusion pressure in 0.1 sec (P0.1) was increased
and negatively associated with FVC; and e) increases in P0.1, mean
inspiratory flow (Vt/Ti) and presence of respiratory alkalosis confirmed the
increase in ventilatory drive. Despite inspiratory muscle weakness in patients,
P0.1/Pimax averaged 5-fold higher than in control subjects. Conclusions:
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