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不同物种中Dmrt1在性别发育中的功能研究
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Abstract:
Dmrt是一个从低等动物到高等动物之间都具有高度保守性且与性别决定和分化密切相关的基因家族。尽管不同物种间性别发育的遗传控制存在差异，但Dmrt1已被广泛证实在雄性的性别决定和精巢的性腺分化及维持中行使重要功能。本文重点从Dmrt基因家族的分类和Dmrt1在不同物种性别发育中的功能研究展开了综述，以期为性别决定基因的分子调控机制和发展人工性别控制育种提供理论依据。
As a gene family related to sex determination and differentiation, Dmrt is highly conserved from lower animals to higher animals. Despite the differences of sex control mechanisms among species, Dmrt1 has been widely related to male sex determination, testis differentiation and maintenance. This review focused on the classification of Dmrt gene family and the functional studies of Dmrt1 related to gender development in different species, which would probably offer insights into the sex-determination mechanisms and artificial sex-controlled breeding.
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