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长期口服小剂量胺碘酮致严重肝损伤1例并文献复习
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Abstract:
胺碘酮是常用的广谱抗心律失常药物，广泛用于治疗和预防多种心律失常性疾病。长期口服胺碘酮可引起心动过缓、甲状腺功能异常、肺毒性、血管异常、胃肠道反应等副作用，而肝毒性相对少见，仅有不到1%的患者出现明显的肝毒性，重度肝损伤更是罕见。现报道1例长期口服小剂量胺碘酮引起的重度肝损伤，讨论病因临床特点、治疗及预后，为口服胺碘酮用药安全提供参考。
Amiodarone is a common broad-spectrum antiarrhythmic drug, which is widely used to treat and prevent a variety of arrhythmia diseases. Long-term oral amiodarone can cause bradycardia, thyroid dysfunction, pulmonary toxicity, vascular abnormalities, gastrointestinal reactions and other side effects, while hepatotoxicity is relatively rare, with less than 1% of patients showing obvious hepatotoxicity, and severe liver injury is even rarer. This paper reports a case of severe liver injury caused by long-term oral low-dose amiodarone, and discusses the etiology, clinical characteristics, treatment and prognosis, so as to provide reference for the safety of oral amiodarone.
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