|
|
胆红素水平与冠心病关系的研究进展
|
Abstract:
冠状动脉粥样硬化性心脏病(CHD)是一种常见的心血管疾病，随着人们社会生活水平的提高和饮食结构的改变，冠心病的发病率逐年增长，成为心血管系统疾病的最重要疾病之一。上世纪60年代初，美国完成了一项具有划时代意义的大型流行病学研究——Framingham研究，从此人们的认知中多了CHD危险因素这一重要概念，而胆红素(Bilirubin, BIL)属于其中较具代表性的一种，通过检测血清中BIL的浓度，可能对CHD的早期预测以及冠脉病变程度的评判有着极其重要的价值。一些学者认为BIL是冠心病的保护因素，但也有研究表明BIL与CHD的发生不相关甚至呈正相关，本文就BIL与CHD的关系做如下综述。
Coronary artery atherosclerotic heart disease is a common cardiovascular disease. With the improvement of people’s social living standards and changes in dietary structure, the incidence of coronary heart disease has been increasing year by year, becoming one of the most important diseases in the cardiovascular system. In the early 1960s, a groundbreaking large-scale epidemiological study called the Framingham Study was completed in the United States. Since then, people have gained an important concept of CHD risk factors. Bilirubin (BIL) is one representative factor among them. By detecting the concentration of BIL in serum, it may have significant value for early prediction of CHD and evaluation of coronary artery lesions. Some scholars believe that BIL is a protective factor for coronary heart disease, but there are also studies showing that BIL is not related to or even positively correlated with CHD occurrence. This article provides a review on the relationship between BIL and CHD as follows.
| [1] | Zhang, H., Jing, L., Zhai, C., Xiang, Q., Tian, H. and Hu, H. (2022) Intestinal Flora Metabolite Trimethylamine Oxide Is Inextricably Linked to Coronary Heart Disease. Journal of Cardiovascular Pharmacology, 81, 175-182. https://doi.org/10.1097/fjc.0000000000001387 |
| [2] | McManus, D.D., Gore, J., Yarzebski, J., Spencer, F., Lessard, D. and Goldberg, R.J. (2011) Recent Trends in the Incidence, Treatment, and Outcomes of Patients with STEMI and NSTEMI. The American Journal of Medicine, 124, 40-47. https://doi.org/10.1016/j.amjmed.2010.07.023 |
| [3] | Du, J., Wu, W., Zhu, B., Tao, W., Liu, L., Cheng, X., et al. (2023) Recent Advances in Regulating Lipid Metabolism to Prevent Coronary Heart Disease. Chemistry and Physics of Lipids, 255, Article ID: 105325. https://doi.org/10.1016/j.chemphyslip.2023.105325 |
| [4] | Li, K., Yang, X., Wang, L., Chen, M., Zhao, W., Xu, L., et al. (2016) Modification of the Association between Smoking Status and Severity of Coronary Stenosis by Vitamin D in Patients Suspected of Coronary Heart Disease. Medicine, 95, e4817. https://doi.org/10.1097/md.0000000000004817 |
| [5] | 曲政, 尤斌, 李平. 不同年龄段早发冠心病患者临床特征及危险因素的分析[J]. 心肺血管病杂志, 2024, 43(5): 433-437. |
| [6] | Jain, V., Ghosh, R.K., Bandyopadhyay, D., Kondapaneni, M., Mondal, S., Hajra, A., et al. (2021) Serum Bilirubin and Coronary Artery Disease: Intricate Relationship, Pathophysiology, and Recent Evidence. Current Problems in Cardiology, 46, Article ID: 100431. https://doi.org/10.1016/j.cpcardiol.2019.06.003 |
| [7] | Leyva, F. (1998) Uric Acid in Chronic Heart Failure: A Marker of Chronic Inflammation. European Heart Journal, 19, 1814-1822. https://doi.org/10.1053/euhj.1998.1188 |
| [8] | Ames, B.N., Cathcart, R., Schwiers, E. and Hochstein, P. (1981) Uric Acid Provides an Antioxidant Defense in Humans against Oxidant-and Radical-Caused Aging and Cancer: A Hypothesis. Proceedings of the National Academy of Sciences of the United States of America, 78, 6858-6862. https://doi.org/10.1073/pnas.78.11.6858 |
| [9] | Hink, H.U., Santanam, N., Dikalov, S., McCann, L., Nguyen, A.D., Parthasarathy, S., et al. (2002) Peroxidase Properties of Extracellular Superoxide Dismutase: Role of Uric Acid in Modulating in Vivo Activity. Arteriosclerosis, Thrombosis, and Vascular Biology, 22, 1402-1408. https://doi.org/10.1161/01.atv.0000027524.86752.02 |
| [10] | Papezikova, I., Pekarova, M., Lojek, A., et al. (2009) The Effect of Uric Acid on Homocysteine-Induced Endothelial Dysfunction in Bovine Aortic Endothelial Cells. Neuro Endocrinology Letters, 30, 112-115. |
| [11] | Sedlak, T.W., Saleh, M., Higginson, D.S., Paul, B.D., Juluri, K.R. and Snyder, S.H. (2009) Bilirubin and Glutathione Have Complementary Antioxidant and Cytoprotective Roles. Proceedings of the National Academy of Sciences of the United States of America, 106, 5171-5176. https://doi.org/10.1073/pnas.0813132106 |
| [12] | Samb, A., Taillé, C., Almolki, A., Mégret, J., Staddon, J.M., Aubier, M., et al. (2002) Heme Oxygenase Modulates Oxidant-Signaled Airway Smooth Muscle Contractility: Role of Bilirubin. American Journal of Physiology-Lung Cellular and Molecular Physiology, 283, L596-L603. https://doi.org/10.1152/ajplung.00446.2001 |
| [13] | Öllinger, R., Bilban, M., Erat, A., Froio, A., McDaid, J., Tyagi, S., et al. (2005) Bilirubin: A Natural Inhibitor of Vascular Smooth Muscle Cell Proliferation. Circulation, 112, 1030-1039. https://doi.org/10.1161/circulationaha.104.528802 |
| [14] | Greabu, M., Olinescu, R., Kummerow, F.A. and Crocnan, D.O. (2001) The Levels of Bilirubin May Be Related to an Inflammatory Condition in Patients with Coronary Heart Disease. Acta Poloniae Pharmaceutica, 58, 225-231. |
| [15] | Hwang, H., Lee, S. and Kim, S. (2011) Relationship between Bilirubin and C-Reactive Protein. Clinical Chemistry and Laboratory Medicine, 49, 1823-1828. https://doi.org/10.1515/cclm.2011.662 |
| [16] | Ghem, C., Sarmento-Leite, R.E., de Quadros, A.S., Rossetto, S. and Gottschall, C.A.M. (2010) Serum Bilirubin Concentration in Patients with an Established Coronary Artery Disease. International Heart Journal, 51, 86-91. https://doi.org/10.1536/ihj.51.86 |
| [17] | 李鲁, 张迪, 杨淑彬. 血清胆红素、尿酸联合同型半胱氨酸检测对冠心病的诊断价值[J]. 陕西医学杂志, 2022, 51(12): 1589-1592. |
| [18] | Xiao, J., Lu, Y. and Yang, X. (2020) Ultrasound Detection of Epicardial Adipose Tissue Combined with Ischemic Modified Albumin in the Diagnosis of Coronary Heart Disease. The Heart Surgery Forum, 23, E461-E464. https://doi.org/10.1532/hsf.3015 |
| [19] | Villelabeitia-Jaureguizar, K., Vicente-Campos, D., Berenguel Senen, A., Hernández Jiménez, V., Ruiz Bautista, L., Barrios Garrido-Lestache, M.E. and López Chicharro, J. (2019) Mechanical Efficiency of High versus Moderate Intensity Aerobic Exercise in Coronary Heart Disease Patients: A Randomized Clinical Trial. Cardiology Journal, 26, 130-137. |
| [20] | Oda, E. and Kawai, R. (2011) A Possible Cross-Sectional Association of Serum Total Bilirubin with Coronary Heart Disease and Stroke in a Japanese Health Screening Population. Heart and Vessels, 27, 29-36. https://doi.org/10.1007/s00380-011-0123-7 |
| [21] | Gupta, N., Singh, T., Chaudhary, R., Garg, S.K., Sandhu, G.S., Mittal, V., et al. (2016) Bilirubin in Coronary Artery Disease: Cytotoxic or Protective? World Journal of Gastrointestinal Pharmacology and Therapeutics, 7, 469-476. https://doi.org/10.4292/wjgpt.v7.i4.469 |
| [22] | Stender, S., Frikke‐Schmidt, R., Nordestgaard, B.G., Grande, P. and Tybjærg‐Hansen, A. (2012) Genetically Elevated Bilirubin and Risk of Ischaemic Heart Disease: Three Mendelian Randomization Studies and a Meta‐Analysis. Journal of Internal Medicine, 273, 59-68. https://doi.org/10.1111/j.1365-2796.2012.02576.x |
| [23] | 丁宁, 陈长强, 樊绮诗. 红细胞分布宽度、血清总胆红素与冠心病及冠状动脉病变程度相关性研究[J]. 检验医学, 2019, 34(10): 889-893. |
| [24] | 李姗茜. 冠状动脉病变程度与血清胆红素水平、炎性指标的相关性研究[D]: [硕士学位论文]. 洛阳: 河南科技大学, 2018. |
| [25] | 崔妍. 纤维蛋白原、脂蛋白a、胆红素等因素与冠脉病变程度的关系[D]: [硕士学位论文]. 长春: 吉林大学, 2016. |
| [26] | Akboga, M.K., Canpolat, U., Sahinarslan, A., Alsancak, Y., Nurkoc, S., Aras, D., et al. (2015) Association of Serum Total Bilirubin Level with Severity of Coronary Atherosclerosis Is Linked to Systemic Inflammation. Atherosclerosis, 240, 110-114. https://doi.org/10.1016/j.atherosclerosis.2015.02.051 |
| [27] | Turfan, M., Duran, M., Poyraz, F., Yayla, C., Akboga, M.K., Sahinarslan, A., et al. (2013) Inverse Relationship between Serum Total Bilirubin Levels and Severity of Disease in Patients with Stable Coronary Artery Disease. Coronary Artery Disease, 24, 29-32. https://doi.org/10.1097/mca.0b013e32835b0c13 |
| [28] | Sahin, O., Akpek, M., Elcik, D., Karadavut, S., Simsek, V., Tulmac, M., et al. (2012) Bilirubin Levels and the Burden of Coronary Atherosclerosis in Patients with STEMI. Angiology, 64, 200-204. https://doi.org/10.1177/0003319712440619 |
| [29] | Kaya, M.G., Sahin, O., Akpek, M., Duran, M., Uysal, O.K., Karadavut, S., et al. (2013) Relation between Serum Total Bilirubin Levels and Severity of Coronary Artery Disease in Patients with Non-St-Segment Elevation Myocardial Infarction. Angiology, 65, 245-249. https://doi.org/10.1177/0003319713504820 |
| [30] | Canpolat, U., Aytemir, K., Yorgun, H., Hazırolan, T., Kaya, E.B., Şahiner, L., et al. (2013) Association of Serum Total Bilirubin Levels with the Severity, Extent and Subtypes of Coronary Atherosclerotic Plaques Detected by Coronary CT Angiography. The International Journal of Cardiovascular Imaging, 29, 1371-1379. https://doi.org/10.1007/s10554-013-0209-7 |
| [31] | Zhu, K., Wang, Y., Wang, Y. and Wang, N. (2016) The Relationship between Serum Levels of Total Bilirubin and Coronary Plaque Vulnerability. Coronary Artery Disease, 27, 52-58. https://doi.org/10.1097/mca.0000000000000309 |
| [32] | Xu, C., Dong, M., Deng, Y., Zhang, L., Deng, F., Zhou, J., et al. (2019) Relation of Direct, Indirect, and Total Bilirubin to Adverse Long-Term Outcomes among Patients with Acute Coronary Syndrome. The American Journal of Cardiology, 123, 1244-1248. https://doi.org/10.1016/j.amjcard.2019.01.019 |
