|
|
对“心肠轴”的研究进展
|
Abstract:
近年来由于心血管疾病的发病率越来越高，人们也在不断寻找治疗心血管疾病的新途径，随着心肠轴概念被提出，人们对肠道菌群与心血管疾病的认识也更加深刻。本文以心肠轴为基础，主要对肠道菌群与心血管疾病的相关性作出综述，以期望为心血管疾病的治疗提供新的思路。
In recent years, due to the increasing incidence of cardiovascular diseases, people are constantly looking for new ways to treat cardiovascular diseases. With the concept of heart-intestines axis proposed, people have a more profound understanding of intestinal flora and cardiovascular diseases. Based on the heart-intestines axis, this paper mainly reviews the correlation between intestinal flora and cardiovascular diseases, hoping to provide new ideas for the treatment of cardiovascular diseases.
| [1] | 金镇, 陈利国, 向明芝, 杜菁宁. 基于“心与小肠相表里”理论从小肠论治慢性心力衰竭[J]. 中国民间疗法, 2020, 28(23): 1-2. |
| [2] | 何佳美, 银子涵, 梁繁荣. 基于“心合小肠”理论探讨针灸调控肠道菌群治疗心血管疾病的可行性[J]. 陕西中医, 2021, 42(11): 1581-1585. |
| [3] | Mueller, N.T., Differding, M.K., Sun, H., Wang, J., Levy, S., Deopujari, V., et al. (2023) Maternal Bacterial Engraftment in Multiple Body Sites of Cesarean Section Born Neonates After Vaginal Seeding—A Randomized Controlled Trial. mBio, 14, e0049123. https://doi.org/10.1128/mbio.00491-23 |
| [4] | Rachid, R., Stephen-Victor, E. and Chatila, T.A. (2021) The Microbial Origins of Food Allergy. Journal of Allergy and Clinical Immunology, 147, 808-813. https://doi.org/10.1016/j.jaci.2020.12.624 |
| [5] | Kamo, T., Akazawa, H., Suzuki, J. and Komuro, I. (2017) Novel Concept of a Heart-Gut Axis in the Pathophysiology of Heart Failure. Korean Circulation Journal, 47, 663-669. https://doi.org/10.4070/kcj.2017.0028 |
| [6] | 中国高血压防治指南修订委员会, 高血压联盟(中国), 中华医学会心血管病学分会, 等. 中国高血压防治指南(2018年修订版) [J]. 中国心血管杂志, 2019, 24(1): 24-56. |
| [7] | 魏康, 姜宁宁, 申意伟, 等. 肠道菌群与高血压的机制探讨及相关治疗[J]. 重庆医学, 2022, 51(11): 1963-1967. |
| [8] | 赵鹏, 刘新新, 田进伟. 肠道菌群代谢物与心血管疾病关系的研究进展[J]. 中国动脉硬化杂志, 2021, 29(12): 1094-1098. |
| [9] | 周嘉, 李宾公. 肠道菌群及其代谢产物氧化三甲胺在心血管疾病中的研究进展[J]. 广东医学, 2020, 41(24): 2590-2593. |
| [10] | 陈晓玲, 韩岩智. 肠道菌群与肥胖相关性高血压的研究进展[J]. 中国社区医师, 2021, 37(25): 7-8. |
| [11] | 陈扬平, 陈维玉, 张秋霞, 修建成. 不同临床分型冠心病患者的肠道菌群多样性分析[J]. 实用医学杂志, 2020, 36(13): 1754-1758. |
| [12] | 李俊艳, 孙致远, 袁宇. 基于高通道测序的肠道菌群与冠心病的相关性研究[J].中国全科医学, 2019, 22(29): 3554-3560. |
| [13] | 陈梦琪, 刘正霞, 鲁翔. 肠道菌群及其代谢产物对冠心病影响的研究进展[J]. 实用老年医学, 2021, 35(9): 971-974. |
| [14] | 孙静, 刘赫昆. 基于“心与小肠相表里”的冠心病与肠道微生态的关系探讨[J]. 时珍国医国药, 2021, 32(10): 2482-2485. |
| [15] | 王焕辉, 王蓓, 覃咏梅, 等. 氧化三甲胺致动脉粥样硬化作用及其防治的研究进展[J]. 中国动脉硬化杂志, 2019, 27(2): 175-179. |
| [16] | 李靖, 任澎, 努尔比耶∙麦麦提, 赵增. 三甲胺-N-氧化物与冠心病和心力衰竭的研究进展[J]. 心血管病学进展, 2020, 41(3): 272-276. |
| [17] | 李丽, 张昕, 邹琳. 基于基因组学与代谢组学分析肠道菌群及其代谢物改变与心力衰竭发生的相关性[J]. 安徽医科大学学报, 2022, 57(3): 407-412. |
| [18] | 袁源, 练桂丽, Robles-Vera, I., Toral, M., de la Visitación, N., Sánchez, M., Gómez-Guzmán, M., Romero, M., Yang, T., Izquierdo-Garcia, J.L., Jiménez, R., Ruiz-Cabello, J., Guerra-Hernández, E., Raizada, M.K., Pérez-Vizcaíno, F., Duarte, J. 益生菌抑制自发性高血压大鼠的菌群失调和血压升高: 短链脂肪酸的作用[J]. 中华高血压杂志, 2020, 28(9): 899. |
| [19] | 王波, 陈翔, 史承勇. 益生菌对稳定性冠心病患者血清TMAO水平的影响及与血清炎性因子水平的相关性[J]. 中国微生态学杂志, 2019, 31(5): 556-559, 563. |
| [20] | 丁洁, 敬怀志, 王遵怜, 杨强. 基于肠道菌群探讨益生菌对慢性心衰患者的影响研究[J]. 海南医学院学报, 2021, 27(4): 260-264. |
| [21] | 李洁白, 袁慧婵, 赵静, 沈晓旭. 补阳还五汤对心衰大鼠肠道菌群及TMAO的影响[J]. 世界中西医结合杂志, 2020, 15(10): 1814-1818. |
| [22] | 彭金祥. 健脾化滞丸对慢性心力衰竭急性加重患者肠道菌群调节作用临床研究[J]. 亚太传统医药, 2020, 16(6): 140-142. |
| [23] | Zhou, G., Jiang, Y., Ma, D., Wang, Y., Yang, J., Chen, J., et al. (2019) Xiao-qing-long Tang Prevents Cardiomyocyte Hypertrophy, Fibrosis, and the Development of Heart Failure with Preserved Ejection Faction in Rats by Modulating the Composition of the Gut Microbiota. BioMed Research International, 2019, Article ID: 9637479. https://doi.org/10.1155/2019/9637479 |
| [24] | 王伟浩. 抗生素、益生菌与肠道微生态的平衡[J]. 中国当代医药, 2009, 16(8): 182, 185 |
| [25] | 纪伟, 刘相良, 刘鹏飞, 赵懿馨, 崔久嵬, 李薇. 人体肠道菌群与抗生素应用[J]. 肿瘤代谢与营养电子杂志, 2021, 8(3): 332-337. |
| [26] | Conraads, V.M., Jorens, P.G., De Clerck, L.S., Van Saene, H.K., Ieven, M.M., Bosmans, J.M., et al. (2004) Selective Intestinal Decontamination in Advanced Chronic Heart Failure: A Pilot Trial. European Journal of Heart Failure, 6, 483-491. https://doi.org/10.1016/j.ejheart.2003.12.004 |
| [27] | Borshchev, Y.Y., Minasian, S.M., Burovenko, I.Y., Borshchev, V.Y., Protsak, E.S., Semenova, N.Y., et al. (2019) Effects of Tetracycline on Myocardial Infarct Size in Obese Rats with Chemically-Induced Colitis. PLOS ONE, 14, e0225185. https://doi.org/10.1371/journal.pone.0225185 |
| [28] | Jia, Q., Li, H., Zhou, H., Zhang, X., Zhang, A., Xie, Y., et al. (2019) Role and Effective Therapeutic Target of Gut Microbiota in Heart Failure. Cardiovascular Therapeutics, 2019, Article ID: 5164298. https://doi.org/10.1155/2019/5164298 |
| [29] | Gregory, J.C., Buffa, J.A., Org, E., Wang, Z., Levison, B.S., Zhu, W., et al. (2015) Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation. Journal of Biological Chemistry, 290, 5647-5660. https://doi.org/10.1074/jbc.m114.618249 |
