Spot-test identification and rapid quantitative sequential analysis of dipyrone

a qualitative spot-test and tandem quantitative analysis of dipyrone in the bulk drug and in pharmaceutical preparations is proposed. the formation of a reddish-violet color indicates a positive result. in sequence a quantitative procedure can be performed in the same flask. the quantitative results obtained were statistically compared with those obtained with the method indicated by the brazilian pharmacopoeia, using the student's t and the f tests. considering the concentration in a 100 μl aliquot, the qualitative visual limit of detection is about 5×10-6 g; instrumental lod ？ 1.4×10-4 mol l-1 ; loq ？ 4.5×10-4 mol l-1.