Novos anticoagulantes orais no tromboembolismo venoso e fibrilha？？o auricular

for more than 50 years, vitamin k antagonists were the only oral anticoagulants available. the unpredictability of its pharmacokinetics and pharmacodynamics, responsible for its difficult clinical management, has raised the need of new anticoagulants. results of trials involving the new anticoagulants in venous thromboembolism and atrial fibrillation are now available and reviewed in this paper.